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Cantharidin

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Company Name: Mainchem Co., Ltd.
Tel: +86-0592-6210733
Email: sales@mainchem.com
Products Intro: Product Name:Cantharidin
CAS:56-25-7
Company Name: ATK CHEMICAL COMPANY LIMITED
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Products Intro: Product Name:4,7-Epoxyisobenzofuran-1,3-dione, hexahydro-3a,7a-dimethyl-, (3aR,4S,7R,7aS)-rel-
CAS:56-25-7
Purity:98% Package:25G;50G;100G;500G;1KG;10KG;50KG
Company Name: Chengdu Biopurify Phytochemicals Ltd.
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Products Intro: Product Name:Cantharidin
CAS:56-25-7
Purity:98% HPLC Package:20mg;100mg;500mg;1g Remarks:BP0309
Company Name: career henan chemical co
Tel: +86-371-86658258
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Products Intro: Product Name:Cantharidin
CAS:56-25-7
Purity:99% Package:1KG;85USD
Company Name: Baoji Herbest Bio-Tech Co.,Ltd.  Gold
Tel: +86-917-8888998
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Lastest Price from Cantharidin manufacturers

  • Cantharidin
  • US $85.00 / KG
  • 2018-08-01
  • CAS:56-25-7
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: customise
Cantharidin Basic information
Description References
Product Name:Cantharidin
Synonyms:(1r,2s,3r,6s)-1,2-dimethyl-3,6-epoxycyclohexane-1,2-dicarboxylic anhydride;4,7-EPOXYISOBENZOFURAN-1,3-DIONE,HEXAHYDRO-3A,7A-DIMETHYL-, (3A,4,7,7A)-;(3A-ALPHA,4B,7B,7A-ALPHA)-HEXAHYDRO-3A,7A-DIMETHYL-4,7-EPOXYISOBENZOFURAN-1,3-DIONE;(3AA,4B,7B,7AA)-HEXAHYDRO-3A,7A-DIMETHYL-4,7-EPOXYISOBENZOFURAN-1,3-DIONE;CANTHARIDIN;dimethyl-3,6-epoxyperhydrophthalic anhydride;HEXAHYDRO-3A,7A-DIMETHYL-4,7-EPOXYISOBENZO-FURAN-1,3-DIONE;4,7-epoxyisobenzofuran-1,3-dione,hexahydro-3a,7a-dimethyl-,(3a-alpha,4-beta
CAS:56-25-7
MF:C10H12O4
MW:196.2
EINECS:200-263-3
Product Categories:chiral;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors
Mol File:56-25-7.mol
Cantharidin Structure
Cantharidin Chemical Properties
Melting point 215-217 °C(lit.)
Boiling point 253.08°C (rough estimate)
density 1.0357 (rough estimate)
refractive index 1.4699 (estimate)
storage temp. Store at RT
solubility Soluble in DMSO (25 mg/ml warm), acetone (8 mg/ml), ethanol (8 mg/ml warm), chloroform (1:65), ether (1:560), and ethyl acetate (1:150).
form solution
color white
Merck 14,1752
InChIKeyDHZBEENLJMYSHQ-XCVPVQRUSA-N
CAS DataBase Reference56-25-7(CAS DataBase Reference)
NIST Chemistry ReferenceCantharidin(56-25-7)
EPA Substance Registry System4,7-Epoxyisobenzofuran- 1,3-dione, hexahydro-3a,7a-dimethyl-, (3aR,4S,7R,7aS)-rel-(56-25-7)
Safety Information
Hazard Codes T+,T
Risk Statements 28-36/37/38-38-37-36-23/24/25
Safety Statements 53-45-36/37/39
RIDADR UN 2811 6.1/PG 1
WGK Germany 3
RTECS RN8575000
TSCA Yes
HazardClass 6.1(a)
PackingGroup I
HS Code 29329990
Hazardous Substances Data56-25-7(Hazardous Substances Data)
MSDS Information
Cantharidin Usage And Synthesis
DescriptionCantharidin is a natural toxicant of blister beetles. Cantharidin has been used as a medicinal agent for over 2000 years and is listed as a drug under the name of Mylabris in the medical monograph Materia Medica published in 77 AD. Some of the most ancient Chinese prescriptions (306–168 BC) refer to the use of Mylabris for the treatment of furuncles and piles.
Cantharidin can be used for topically (0.7%) treatment of warts, in which the skin under the wart blisters, thereby, lifting the wart off the skin. It is used to treat molluscum contagiosum. Cantharidin is a strong inhibitor of protein phosphatases types 1 (PP1) and 2A (PP2A), which are potentially novel targets for anticancer therapies. Thus, cantharidin is exploited as anticancer drugs. Cantharidin is shown to be cytotoxic to cancer cells and stimulatory on the bone marrow. The renal toxicity of this drug has prevented its use in mainstream oncology.
References[1] Richard E. Honkanen (1993) Cantharidin, another natural toxin that inhibits the activity of serin/threonine protein phosphatases types 1 and 2A, 330, 283-286
[2] Jennette A. Sakoff, Stephen P. Ackland, Monique L. Baldwin, Mirella A. Keane, Adam
McCluskey (2002) Anticancer activity and protein phosphatase 1 and 2A inhibition of a new generation of cantharidin analogues, 20, 1-11
[3] Erin F. D. Mathes, Ilona J. Frieden (2010) Treatment of molluscum contagiosum with cantharidin: a practical approach, 39, 124-130
Chemical Propertieswhite to light yellow crystal powde
Chemical PropertiesCantharidin is a brown to black powder.
UsesIn veterinary medicine as a vesicant, rubefa- cient, and counterirritant.
DefinitionChEBI: A monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria. Natural toxin inhibitor of protein phosphatases 1 and 2A.
UsesCantharidin is a natural toxin produced by blister beetles that moderately inhibits protein phosphatases 1 (PP1) (IC50 = 1.7 μM) and PP2A (IC50 = 0.2 μM) and only weakly inhibits the activity of PP2B (IC50 = 1 mM). It has been shown to stimulate cell cycle progression and induce premature mitosis, used topically (0.7%) as an anti-wart treatment, and has been shown to be active in cervical, tongue, neuroblastoma, bone, leukemia, ovarian, colon, and various other cancer cell lines.
General DescriptionBrown to black powder or plates or scales. Formerly used as a counterirritant and vesicant. Used for the removal of warts. Used as an experimental anti tumor agent. Active ingredient in spanish fly, a reputed aphrodisiac.
Reactivity ProfileOrganic anhydrides, such as Cantharidin, are incompatible with acids, strong oxidizing agents, alcohols, amines, and bases.
HazardExtremely toxic; questionable carcinogen; powerful irritant to all cells and tissues; deadly poi- son; respiratory failure; death.
Health HazardCantharidin is classified as super toxic. Probable oral lethal dose in humans is less than 5 mg/kg or a taste of less than 7 drops for a 70 kg (150 lb.) person. It is very toxic by absorption through skin.
Fire HazardWhen heated to decomposition Cantharidin emits acrid smoke and irritating fumes.
Biological ActivityNatural toxin inhibitor of protein phosphatases 1 and 2A (K i values are 1.1 and 0.19 μ M respectively); similar to okadaic acid (9,10-Deepithio-9,10-didehydroacanthifolicin ). Displays > 500-fold selectivity over PP2B.
Potential ExposureFormerly used as a counterirritant and vesicant. Also used for the removal of benign epithelial growths, e.g., warts. Used as an experimental antitumor agent. The active ingredient in “Spanish fly,” a reputed aphrodisia
First aidIf this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. For ingestion, induce vomiting with syrup of ipecac
ShippingCantharidin is not specifically listed in the DOT Performance-Oriented Packaging Standards with respect to labeling requirements or restrictions on shipping quantities.
Waste DisposalIt is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged, and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.
Tag:Cantharidin(56-25-7) Related Product Information
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