|
|
| | (R)-2-Phenyl-3-methylbutanoic acid Basic information |
| Product Name: | (R)-2-Phenyl-3-methylbutanoic acid | | Synonyms: | (R)-2-Phenyl-3-methylbutanoic acid;[R,(-)]-3-Methyl-2-phenylbutyric acid;(alphaR)-alpha-(1-Methylethyl)benzeneacetic acid;Benzeneacetic acid, .alpha.-(1-methylethyl)-, (.alpha.R)-;(R)-3-Methyl-2-phenylbutanoic acid;Benzeneacetic acid, α-(1-methylethyl)-, (αR)-;(aR)-alpha-(1-Methylethyl)-benzeneacetic acid | | CAS: | 13491-13-9 | | MF: | C11H14O2 | | MW: | 178.23 | | EINECS: | | | Product Categories: | | | Mol File: | 13491-13-9.mol |  |
| | (R)-2-Phenyl-3-methylbutanoic acid Chemical Properties |
| density | 1.063 | | storage temp. | Sealed in dry,Room Temperature | | Appearance | White to off-white Solid |
| | (R)-2-Phenyl-3-methylbutanoic acid Usage And Synthesis |
| Synthesis | General procedure for the synthesis of (R)-3-methyl-2-phenylbutyric acid from 3-methyl-2-phenylbutyric acid: 2-isopropylphenylacetic acid (8.91 g), (+)-α-phenylethylamine (6.45 mL), and 63% aqueous ethanol (193 mL) were mixed, and the reaction was slowed and cooled by reflux. The resulting salt was purified by three recrystallizations from 63% aqueous ethanol solution. Subsequently, the salt was treated with 10% sulfuric acid at 0 °C, the reaction mixture was extracted with ethyl acetate, and the organic phase was dried and concentrated to give 3.52 g of (R)-(-)-2-isopropylphenylacetic acid in 39% yield, [α]25D -58.6° (CHCl3, c = 0.02). | | References | [1] European Journal of Medicinal Chemistry, 2017, vol. 140, p. 42 - 51
[2] Chemical Communications, 2006, # 34, p. 3600 - 3602 |
| | (R)-2-Phenyl-3-methylbutanoic acid Preparation Products And Raw materials |
|