牛磺鹅去氧胆酸钠
中文名称 | 牛磺鹅去氧胆酸钠 |
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中文同义词 | 牛磺去氧鹅胆酸钠;牛磺鹅脱氧胆酸钠;牛磺鹅去氧胆酸钠;牛磺鹅脱氧胆酸钠盐;熊去氧胆酸杂质15;牛磺鹅去氧胆酸钠(TCDCA);牛磺鹅去氧胆酸-[D4]钠盐;牛磺鹅去氧胆酸-[D9]钠盐 |
英文名称 | TAUROCHENODEOXYCHOLIC ACID SODIUM SALT |
英文同义词 | Sodium taurochenodeoxycholate,2-([3α,7α-Dihydroxy-24-oxo-5β-cholan-24-yl]amino)ethanesulfonic acid sodium salt, 3α,7α-Dihydroxy-5β-cholan-24-oic acid N-(2-sulfoethyl)amide sodium salt, Taurochenodeoxy;taurochenodeoxycholic acid soduim salt;3α,7α-Dihydroxy-5β-cholan-24-oic acid N-(2-sulfoethyl)amide sodium salt;Taurochenodeoxycholic Acid D4 Sodium Salt;2-([3-ALPHA,7-ALPHA-DIHYDROXY-24-OXO-5-BETA-CHOLAN-24-YL]AMINO)ETHANESULFONIC ACID;2-[(3ALPHA,7ALPHA-DIHYDROXY-24-OXO-5BETA-CHOLAN-24-YL)AMINO]ETHANESULFONIC ACID SODIUM SALT;5-BETA-CHOLANIC ACID-3-ALPHA, 7-ALPHA-DIOL N-(2-SULPHOETHYL)-AMIDE SODIUM SALT;5BETA-CHOLANIC ACID-3ALPHA,7ALPHA-DIOL-24-N-(2-SULFOETHYL)-AMIDE SODIUM |
CAS号 | 6009-98-9 |
分子式 | C26H44NNaO6S |
分子量 | 521.69 |
EINECS号 | |
相关类别 | 胆酸系列;中间体;中药对照品;分析试剂标准品;标准品 -中药标准品;杂质对照品;生化试剂;临床检测标准物质 |
Mol文件 | 6009-98-9.mol |
结构式 |
牛磺鹅去氧胆酸钠 性质
熔点 | 165-175 °C |
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储存条件 | room temp |
溶解度 | 甲醇(微溶)、水(微溶) |
形态 | 固体 |
颜色 | 白色至类白色 |
BRN | 3901205 |
稳定性 | 吸湿性 |
CAS 数据库 | 6009-98-9(CAS DataBase Reference) |
Human Endogenous Metabolite
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Taurochenodeoxycholic acid dramatically improves the apoptosis rate of NR8383 cells in a concentration-dependent manner. In the meantime, Taurochenodeoxycholic acid significantly augments PKC mRNA levels, activities and increases JNK, caspase-3 and caspase-8 mRNA expression levels, activities.
Taurochenodeoxycholic acid (0.05, 0.1g/kg) decreases the pulmonary coefficient in the model mice and reduces the pathological damages on their lungs; it can decrease the expression levels of TNF-α and TIMP-2 in pulmonary tissues in the pulmonary fibrosis mice and has no significant effects on MMP2.
Taurochenodeoxycholic acid significantly normalizes the clinical inflammatory parameters, prevented indomethacin-induced increases in the biliary contents of secondary bile acids and hydrophobicity index, and tended to attenuate the intestinal inflammation.
Taurochenodeoxycholic acid significantly suppresses paw swelling and polyarthritis index, increases the loss body weight and index of thymus and spleen, and amends radiologic changes in AA rats. The overproduction and mRNA expression of TNF-α, IL-1β and IL-6 are remarkably suppressed in serum and synovium tissue of all TCDCA-treated rats.
提供商 | 语言 |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-N1429 | 牛磺鹅去氧胆酸钠 Taurochenodeoxycholic acid sodium salt | 6009-98-9 | 100mg | 500元 |