Bay 61-3606

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Bay 61-3606 manufacturers

  • BAY 61-3606
  • BAY 61-3606 pictures
  • $51.00
  • 2026-07-27
  • CAS:732983-37-8
  • Purity: 98.72%
  • Supply Ability: 10g
Bay 61-3606 Basic information
Product Name:Bay 61-3606
Synonyms:Syk Inhibitor IV, BAY 61-3606: sc-202351 hydrochloride;Syk Inhibitor IV, BAY 61-3606 HCl;BAY 61-3606 hydrate hydrochloride;2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]-3-pyridinecarboxamide;BAY-61-360;Syk Inhibitor IV, BAY 61-3606;BAY 61-3606 free base;CS-2745
CAS:732983-37-8
MF:C20H18N6O3
MW:390.4
EINECS:
Product Categories:
Mol File:732983-37-8.mol
Bay 61-3606 Structure
Bay 61-3606 Chemical Properties
density 1.41
storage temp. 2-8°C
solubility H2O: soluble
form solid
color yellow
InChI1S/C20H18N6O3/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24-14)25-19-13(18(21)27)4-3-7-23-19/h3-11H,1-2H3,(H2,21,27)(H,23,24,25)
InChIKeyJWQOJVOKBAAAAR-UHFFFAOYSA-N
SMILES[n]21c(ncc2)cc(nc1Nc4ncccc4C(=O)N)c3cc(c(cc3)OC)OC
Safety Information
WGK Germany 3
Storage Class11 - Combustible Solids
MSDS Information
Bay 61-3606 Usage And Synthesis
UsesSyk Inhibitor IV is an imidazopyrimidine inhibitor of Syk and Syk-mediated functions.
DefinitionChEBI: 2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide is a member of pyrimidines.
Biological ActivityCell permeable: yes', 'Primary Target
Syk', 'Product competes with ATP.', 'Reversible: yes
in vivo

Bay 61-3606 (50 mg/kg; administered twice a week for two weeks by intraperitoneal injection) alone leads to more efficacious reductions than that of TNF-related apoptosis-inducing ligand (TRAIL; 10 mg/kg) alone in MCF-7 tumor xenograft-bearing BALB/c nude mice. Bay 61-3606 administered in TRAIL combination significantly reduces the volume of the xenografted tumor[4].

Animal Model:Female BALB/c nude mice (5 weeks old) bearing MCF-7 tumor xenograft[4]
Dosage:50 mg/kg
Administration:Injected intraperitoneally twice a week with Bay 61-3606 (50 mg/kg), TRAIL (10 mg/kg) or a combination of Bay 61-3606 (50 mg/kg) and TRAIL (10 mg/kg); TRAIL was given 2 h after the injection of Bay 61-3606; for two weeks
Result:Led to efficacious reductions in tumor growth.
Bay 61-3606 Preparation Products And Raw materials
Tag:Bay 61-3606(732983-37-8) Related Product Information
Benzyl alcohol 2-Methoxyphenylacetic acid 4'-Hydroxyacetophenone Sodium benzoate Bay 61-3606 Imidazo[1,2-c]pyrimidine, 7-methyl- (9CI)