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| Product Name: | BAY 2416964 | | Synonyms: | AHR antagonist 3;(S)-6-(4-chlorophenyl)-N-(1-hydroxypropan-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)-3-oxo-2,3-dihydropyridazine-4-carboxamide;4-Pyridazinecarboxamide, 6-(4-chlorophenyl)-2,3-dihydro-N-[(1S)-2-hydroxy-1-methylethyl]-2-(1-methyl-1H-pyrazol-4-yl)-3-oxo-;6-(4-chlorophenyl)-N-[(2S)-1-hydroxypropan-2-yl]-2-(1-methylpyrazol-4-yl)-3-oxopyridazine-4-carboxamide;BAY 2416964 USP/EP/BP;BAY241696 | | CAS: | 2242464-44-2 | | MF: | C18H18ClN5O3 | | MW: | 387.82 | | EINECS: | | | Product Categories: | | | Mol File: | 2242464-44-2.mol |  |
| | BAY 2416964 Chemical Properties |
| density | 1.42±0.1 g/cm3(Predicted) | | solubility | DMSO:64.0(Max Conc. mg/mL);165.02(Max Conc. mM) | | pka | 11.81±0.20(Predicted) |
| | BAY 2416964 Usage And Synthesis |
| Use | BAY 2416964 (compound 192) is a potent and orally active antagonist of aryl hydrocarbon receptor (AhR) with IC50 of 341 nM. BAY 2416964 has the potential in the treatment of solid tumors. | | In vitro | BAY 2416964 (Example 192) induces AHR-regulated gene CYP1A1 expression with IC50 of 4.30 nM in a human monocytic U937 cells.
| | In vivo | BAY 2416964 (Example 192) is dissolved in Ethanol/Solutol/Water (10/40/50) and given at 30 mg/kg, QD, p.o.. The efficacy is calculated based on tumor volume. BAY 2416964 (Example 192) is shown to have the potential for solid tumour treatment.
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| | BAY 2416964 Preparation Products And Raw materials |
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