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Product Name: | BAY-885 | Synonyms: | BAY-885;[2-amino-4-(trifluoromethoxy)phenyl]-{4-[7-(4-methylpiperazin-1-yl)pyrido[3,2-d]pyrimidin-4-yl]piperidin-1-yl}methanone;Methanone, [2-amino-4-(trifluoromethoxy)phenyl][4-[7-(4-methyl-1-piperazinyl)pyrido[3,2-d]pyrimidin-4-yl]-1-piperidinyl]-;BAY-885 USP/EP/BP;BAY 885,ERK,inhibit,Extracellular signal regulated kinases,Inhibitor,BAY885,BAY-885 | CAS: | 2307249-33-6 | MF: | C25H28F3N7O2 | MW: | 515.53 | EINECS: | | Product Categories: | | Mol File: | 2307249-33-6.mol | |
| BAY-885 Chemical Properties |
Boiling point | 685.0±55.0 °C(Predicted) | density | 1.362±0.06 g/cm3(Predicted) | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | solubility | DMSO:23.33(Max Conc. mg/mL);45.25(Max Conc. mM) Ethanol:8.0(Max Conc. mg/mL);15.52(Max Conc. mM) | form | A solid | pka | 7.06±0.42(Predicted) |
| BAY-885 Usage And Synthesis |
Use | BAY-885 is a highly potent and selective ERK5 inhibitor. | In vitro | BAY-885 shows potent ERK5 kinase and transcriptional inhibition in the SN12C-MEF2 reporter cell line (IC50 = 115 nM/IC90 = 691 nM) and has no effects on a reporter control cell line with constitutive luciferase expression (SN12C-CMV-luc, IC50 > 30 μM), thereby ruling out potential effects as a general inhibitor of transcription or translation. |
| BAY-885 Preparation Products And Raw materials |
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