|
ChemicalBook Optimization Suppliers |
|
| 化学名: | ピペクロニウム臭化物 | | 英語化学名: | Pipecuronium bromide | | 别名: | pipecuronium bromide;4,4'-((2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)androstane-2,16-diyl)bis(1,1-dimethyl-piperazinium) dibromide;4,4'-[(2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetoxy)androstane-2,16-diyl]bis[1,1-dimethylpiperazinium] dibromide;PIPECURIUM BROMIDE;PIPECURINIUM BROMIDE;4，4’-[(2β，3α，5α，16β，17β)-3，17-Bis(acetoxy)andrc~tane-2，16-diyl]bis(1，1-dimethylpiperazinium)dibromide;Ardtm;Pipecuriurn Brmnide | | CAS番号: | 52212-02-9 | | 分子式: | C35H62Br2N4O4 | | 分子量: | 762.69918 | | EINECS: | 257-740-4 | | カテゴリ情報: | | | Mol File: | 52212-02-9.mol |  |
| 融点 | 262-264° (dec) | | 比旋光度 | D25 +8.1° (c = 1 in water) | | 貯蔵温度 | Store at -20°C | | 溶解性 | DMSO, Methanol (Slightly), Water (Slightly) | | 外見 | Solid | | 色 | White to Off-White | | CAS データベース | 52212-02-9(CAS DataBase Reference) |
| 毒性 | LD50 in mice, rats (mg/kg): 29.7, 172.6 i.v.; 70.6, 449.6 i.p.; 60.5, 455.8 s.c. (Kárpáti, Biro) |
| | ピペクロニウム臭化物 Usage And Synthesis |
| 効能 | 神経筋遮断薬 | | 使用 | Pipecuronium Bromide is a muscle relaxant and an anaesthesia used in patients undergoing coronary artery bypass graft surgery. | | 定義 | ChEBI: Pipecuronium bromide is a steroid ester. | | brand name | Arduan (Organon). | | 一般的な説明 | Pipecurium bromide, 4,4 -(3 ,17 -dihydroxy-5 -androstan-2 ,16 -ylene)bis(1,1-dimeth-ylpiperazinium)dibromide diacetate (Arduan), is anondepolarizing muscle relaxant similar, both chemicallyand clinically, to pancuronium bromide. It is a long-actingdrug indicated as an adjunct to anesthesia and in patients undergoingmechanical ventilation. | | 薬理学 | Pipecuronium bromide, an analogue of pancuronium, was developed in
Hungary in 1980 and is marketed in Eastern Europe and the United S tates.
The intubating dose is 0.07 mg kg–1. The onset time and time to recovery from
block are similar to those of pancuronium, and excretion of
the drug through the kidneys is significant (66%). In contrast to
pancuronium, pipecuronium produces marked cardiovascular stability,
having no vagolytic or sympathomimetic effects. It may therefore be useful
during major surgery in patients with cardiac disease. |
|