1,1,3-三溴丙酮
| 中文名称 | 1,1,3-三溴丙酮 |
|---|---|
| 中文同义词 | 1,1,3-三溴丙酮,甲氨蝶呤中间体;三溴丙酮;1,1,3-三溴丙酮;1,1,1三溴丙酮;1,1,3-三溴丙酮(具备生产资质);1,1,3-三溴丙烷-2-一;1,1,3-三流丙酮 |
| 英文名称 | 1,1,3-Tribromoacetone |
| 英文同义词 | 1,1,3-TribromoAceton;1,1,3-tribromoacetone;1,1,3-Tribromopropan-2-one;2-Propanone,1,1,3-tribromo-;JACS-3475-39-6;TIANFU-CHEM--1,1,3-Tribromoacetone;1,1,3-Tribromo-2-propanone |
| CAS号 | 3475-39-6 |
| 分子式 | C3H3Br3O |
| 分子量 | 294.77 |
| EINECS号 | |
| 相关类别 | 酮类;有机原料;医药中间体;化工原料;原料药及中间体 |
| Mol文件 | 3475-39-6.mol |
| 结构式 |  |
1,1,3-三溴丙酮 性质
| 熔点 | 28-29 °C |
|---|---|
| 沸点 | 114-116 °C(Press: 14 Torr) |
| 密度 | 2.561±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO：100 mg/mL（339.25 mM；需要超声波） |
Methotrexate (Amethopterin) reduces thymus and spleen indices of mice. Methotrexate markedly decreases white blood cells, thymic and splenic lymphocytes at dose ≥5 mg/kg. However, there is a significant difference between the treatment plus control group and the model group (p<0.01). The combination of grape seed proanthocyanidins and Siberian ginseng eleutherosides obviously diminishes the effects of Methotrexate exposure on indices of thymus and spleens in mice. Methotrexate (MTX) (2 mg/kg; i.p.; once in a week for 5 weeks) is effective in Freund's complete adjuvant-induced arthritis. The combination of Methotrexate (1 mg/kg; i.p.; once in a week for 5 weeks) and Curcumin (30 mg/kg and 100 mg/kg, thrice a week for 5 weeks; i.p.) shows a significant anti-arthritic action and protection from hematological toxicity.