QS 21 manufacturers
- QS-21
-
-
2026-05-25
- CAS:141256-04-4
- Purity:
- Supply Ability: 10g
|
| Product Name: | QS 21 | | Synonyms: | QS 21;QS-21 ADJUVANT;QA 21;QA 21V1;QS-21-Api;Saponin QA 21V1;β-D-Glucopyranosiduronic acid, (3β,4α,16α)-28-[[O-D-apio-β-D-furanosyl-(1→3)-O-β-D-xylopyranosyl-(1→4)-O-6-deoxy-α-L-mannopyranosyl-(1→2)-4-O-[5-[[5-(α-L-arabinofuranosyloxy)-3-hydroxy-6-methyl-1-oxooctyl]oxy]-3-hydroxy-6-methyl-1-oxooctyl]-6-deoxy-β-D-galactopyranosyl]oxy]-16-hydroxy-23,28-dioxoole...;(2S,3S,4S,5R,6R)-6-(((3S,4S,4aR,6aR,6bS,8R,8aR,12aS,14aR,14bR)-8a-((((2S,3R,4S,5R,6R)-3-(((2S,3R,4S,5R,6S)-5-(((2S,3R,4S,5R)-4-(((2S,3R,4R)-3,4-Dihydroxy-4-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)-3,5-dihydroxytetrahydro-2H-pyran-2-yl)oxy)-3,4-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-5-(((3S,5S,6S)-5-(((3S,5S,6S)-5-(((2R,3R,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)-3-h | | CAS: | 141256-04-4 | | MF: | C92H148O46 | | MW: | 1990.13 | | EINECS: | | | Product Categories: | | | Mol File: | 141256-04-4.mol |  |
| | QS 21 Chemical Properties |
| density | 1.52±0.1 g/cm3 (20 ºC 760 Torr) | | storage temp. | Store at -20°C | | pka | 2.68±0.70(Predicted) | | form | Solid | | color | White to light yellow | | InChIKey | CNEYUDLWGDOPIY-VWDQBTOUNA-N |
| | QS 21 Usage And Synthesis |
| Uses | QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18[1][2][3]. | | in vivo | Studies in mouse APCs (DCs and macrophages) identifie QS-21 as an activator of the NLRP3 inflammasome, and cause subsequent release of caspase-1 dependent proinflammatory cytokines I1-1β/I1-18 that can promote Th 17 cell maturation or drive INF-γ-mediated Th1 responses, respectively[3]. | | IC 50 | NLRP3 inflammasome | | References | [1] Fernández-Tejada A, et al. Development of Improved Vaccine Adjuvants Based on the Saponin Natural Product QS-21 through Chemical Synthesis. Acc Chem Res. 2016;49(9):1741-1756. DOI:10.1021/acs.accounts.6b00242
[2] Marty-Roix R, et al. Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants. J Biol Chem. 2016;291(3):1123-1136 DOI:10.1074/jbc.M115.683011
[3] Lacaille-Dubois MA. Updated insights into the mechanism of action and clinical profile of the immunoadjuvant QS-21: A review. Phytomedicine. 2019;60:152905. DOI:10.1016/j.phymed.2019.152905 |
| | QS 21 Preparation Products And Raw materials |
|