N,N'-八亚甲基双二氯乙酰胺
| 中文名称 | N,N'-八亚甲基双二氯乙酰胺 |
|---|---|
| 中文同义词 | N,N'-1,8-辛二基双[2,2-二氯]乙酰胺;N,N′-八亚甲基双(2,2-二氯乙酰胺);N,N′-双(二氯乙酰基)-1,8-八亚甲基二胺;佛替来辛;N,N'-八亚甲基双二氯乙酰胺;N,N'-(辛烷-1,8-二基)双(2,2-二氯乙酰胺);N,N'-八亚甲基双二氯乙酰胺,10 MM DMSO 溶液 |
| 英文名称 | N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) |
| 英文同义词 | FERTILYSIN;N,N'-BIS(DICHLOROACETYL)-1,8-OCTAMETHYLENEDIAMINE;N,N'-OCTA-METHYLENE-BIS[2,2-DICHLOROACETAMIDE];N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE);bisdiamine;bis-diamine;n,n’,1,8-octanediylbis(2,2-dichloro-acetamid;n,n’-bis(dichloroacetyl)-1,8-diaminooctane |
| CAS号 | 1477-57-2 |
| 分子式 | C12H20Cl4N2O2 |
| 分子量 | 366.11 |
| EINECS号 | 216-033-0 |
| 相关类别 | 其它 |
| Mol文件 | 1477-57-2.mol |
| 结构式 |  |
N,N'-八亚甲基双二氯乙酰胺 性质
| 熔点 | 118-120 °C |
|---|---|
| 沸点 | 530℃ |
| 密度 | 0.726 |
| 折射率 | 1.6200 (estimate) |
| 闪点 | 275℃ |
| 储存条件 | Inert atmosphere,2-8°C |
| 溶解度 | 可溶于丙酮（非常少量）、DMSO（少量）、甲醇（少量、加热、超声处理) |
| 酸度系数(pKa) | 12.28±0.46(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
| CAS 数据库 | 1477-57-2 |
Win 18446 是具有口服活性的睾丸特异性的酶 ALDH1a2 的抑制剂，其 IC50 值为 0.3 μM。Win 18446 可逆的抑制多个物种的精子形成，抑制睾丸内视黄醇 (HY-B1342) 合成视黄酸 (HY-14649)。
WIN 18446 (1 μM, 24 h) is able to suppress Stra8 expression in whole-testes cultures that contained both germ and somatic cells.
RT-PCR
| Cell Line: | Testes were collected from 2-dpp mice. |
| Concentration: | 1 μM. |
| Incubation Time: | 24 h. |
| Result: |
Results in a VAD-like phenotype in the testis.
Alone or in combination with ROL significantly reduced Stra8 expression. |
Win 18446 (200 mg/kg, Orally for 4, 8, and 16 weeks) significantly reduces intratesticular concentrations of retinoic acid, severely impaired spermatogenesis, and caused infertility.
| Animal Model: | Six-month-old male New Zealand white rabbits. |
| Dosage: | 200 mg/kg. |
| Administration: | Orally for 4, 8, and 16 weeks. |
| Result: |
Resulted in marked suppression of testicular weight over time.
Dramatically suppressed spermatogenesis. Significantly reduces intratesticular concentrations of retinoic acid and Stra8 expression and very severely suppresses spermatogenesis and fertility. |
类别
有毒物品毒性分级
高毒急性毒性
腹腔-小鼠 LDL0: 150 毫克/公斤可燃性危险特性
可燃; 受热产生有毒氮氧化物,氯化物烟雾; 药物副作用:恶心,呕吐,精子形成改变储运特性
库房通风低温干燥; 与食品原料分开存放灭火剂
干粉,泡沫,沙土,二氧化碳, 雾状水安全信息
| 危险品标志 | Xn |
|---|---|
| 危险类别码 | 20/21/22-40 |
| 安全说明 | 24/25-45-36 |
| 毒性 | LD50 orally in mice: >16000 mg/kg (Coulston) |
| 提供商 | 语言 |
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英文
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