| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:METHIOTHEPIN MALEATE
CAS:19728-88-2
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| | METHIOTHEPIN MALEATE Basic information |
| Product Name: | METHIOTHEPIN MALEATE | | Synonyms: | RO 8-6837;1-(10,11-dihydro-8-methylthiodibenzo(b,f)thiepin-10-yl)-4-methyl-piperazin;8-methylthio-10-(4-methylpiperazino)-10,11-dihydrodibenzo(b,f)thiepinmaleate;f)thiepin,10,11-dihydro-10-(4-methylpiperazino)-8-methylthio-dibenzo(hyd;f)thiepin,10,11-dihydro-8-methylthio-10-(4-methylpiperazino)-dibenzo(hyd;metitepinmaleate;Dibenzo(B,F)thiepin, 10,11-dihydro-10-(4-methylpiperazino)-8-methylthio-, hydrogen maleate;Dibenzo(B,F)thiepin, 10,11-dihydro-8-methylthio-10-(4-methylpiperazino)-, hydrogen maleate | | CAS: | 19728-88-2 | | MF: | C24H28N2O4S2 | | MW: | 472.62 | | EINECS: | | | Product Categories: | | | Mol File: | 19728-88-2.mol |  |
| | METHIOTHEPIN MALEATE Chemical Properties |
| Melting point | 171-173° | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | Soluble to 100 mM in DMSO | | form | Powder |
| Toxicity | LD5O in mice (mg/kg): 51 i.v.; 94 orally (Jilek) |
| | METHIOTHEPIN MALEATE Usage And Synthesis |
| Uses | Methiothepin Maleate exhibits anticonvulsant property and it is able to suppress pentylenetetrazol induced fos expression in zebrafish. In addition, Methiothepin Maleate is a 5-HT antagonist. | | Uses | Biochemical tool in serotonin receptor binding studies. | | Definition | ChEBI: A maleate salt obtained by reaction of methiothepin with one equivalent of maleic acid. Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays
ffinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively). |
| | METHIOTHEPIN MALEATE Preparation Products And Raw materials |
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