| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:Methiothepin Maleate;1-[10,11-Dihydro-8-(Methylthio)dibenzo(Z)[b,f]thiepin-10-yl]-4-MethylpiperazineMaleate
CAS:20229-30-5
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
Shanghai Synchem Pharma Co., ltd
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| Tel: |
021-61984905-1 18016477331 |
| Email: |
synchempharma@aliyun.com |
| Products Intro: |
Product Name:METHIOTHEPIN MALEATE
CAS:20229-30-5
Purity:95%+ Package:50g,1kg,25kg or as request
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| Company Name: |
EMMX Biotechnology LLC
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| Tel: |
888-539-0666 |
| Email: |
info@emmx.com |
| Products Intro: |
Product Name:Methiothepin maleate
CAS:20229-30-5
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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| | METHIOTHEPIN MALEATE Basic information |
| Product Name: | METHIOTHEPIN MALEATE | | Synonyms: | 1-[10,11-Dihydro-8-(methylthio)dibenzo(Z)[b,f]thiepin-10-yl]-4-methylpiperazinemaleate;(+-)-1-(10,11-dihydro-8-(methylthio)dibenzo(b,f)thiepin-10-yl)-4-methylpiper;(+-)-10-(4-methylpiperazinyl)-8-(methylthio)-10,11-dihydrodibenzo(b,f)thiepi;(+-)-8-methylthio-10-(4-methylpiperazino)-10,11-dihydrodibenzo(b,f)thiepin;dibenzo(b,f)thiepin,10,11-dihydro-10-(4-methylpiperazinyl)-8-(methylthio)-(;methiothepin;8-Methylthio-10-(4-methylpiperazino)-10,11-dihydrodibenzo[b,f]thiepine;Methiothepine | | CAS: | 20229-30-5 | | MF: | C20H24N2S2 | | MW: | 356.55 | | EINECS: | | | Product Categories: | Serotonin receptor | | Mol File: | 20229-30-5.mol |  |
| | METHIOTHEPIN MALEATE Chemical Properties |
| Melting point | 88-89° | | Boiling point | 462.9±45.0 °C(Predicted) | | density | 1.25±0.1 g/cm3(Predicted) | | storage temp. | Store at RT | | solubility | H2O: 13 mg/mL | | form | solid | | pka | 7.95±0.42(Predicted) | | color | white |
| | METHIOTHEPIN MALEATE Usage And Synthesis |
| Uses | 5HT1&2 receptor antagonist | | Uses | Methiothepin Maleate exhibits anticonvulsant property and it is able to suppress pentylenetetrazol induced fos expression in zebrafish. In addition, Methiothepin Maleate is a 5-HT antagonist. | | Definition | ChEBI: Methiothepin is a dibenzothiepine that is 10,11-dihydrodibenzo[b,f]thiepine bearing additional methylthio and 4-methylpiperazin-1-yl substituents at positions 8 and 10 respectively. Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively). It has a role as an antipsychotic agent, a dopaminergic antagonist, a serotonergic antagonist and a geroprotector. It is a N-alkylpiperazine, a dibenzothiepine, an aryl sulfide and a tertiary amino compound. It is a conjugate base of a methiothepin(2+). | | Biological Activity | Potent 5-HT 2 antagonist, also active as 5-HT 1 antagonist. Differentiates 5-HT 1D sub-types. Also displays affinity for rodent 5-HT 5B , 5-HT 5A , 5-HT 7 and 5-HT 6 receptors (pK 1 values are 6.6, 7.0, 8.4 and 8.7 respectively). |
| | METHIOTHEPIN MALEATE Preparation Products And Raw materials |
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