Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
|
Tel: |
821-50328103-801 18930552037 |
Email: |
3bsc@sina.com |
Products Intro: |
Product Name:RS 23597-190 hydrochloride;3-(Piperidin-1-yl)propyl4-aMino-5-chloro-2-Methoxybenzoatehydrochloride CAS:149719-06-2 Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
|
|
| RS 23597-190 HYDROCHLORIDE Basic information |
Product Name: | RS 23597-190 HYDROCHLORIDE | Synonyms: | 3-(PIPERIDIN-1-YL)PROPYL 4-AMINO-5-CHLORO-2-METHOXYBENZOATE HYDROCHLORIDE;RS 23597-190 HYDROCHLORIDE;RS23597-190HCl;3-(piperidine-1-yl)propyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride;3-piperidin-1-ylpropyl 4-azanyl-5-chloro-2-methoxy-benzoate hydrochloride;4-amino-5-chloro-2-methoxy-benzoic acid 3-piperidinopropyl ester hydrochloride;3-(PIPERIDIN-1-YL)PROPYL-4-AMINO-5-CHLORO-2-METHOXYBENZOATE HCL;4-amino-5-chloro-2-methoxybenzoic acid 3-(1-piperidinyl)propyl ester hydrochloride | CAS: | 149719-06-2 | MF: | C16H24Cl2N2O3 | MW: | 363.28 | EINECS: | | Product Categories: | | Mol File: | 149719-06-2.mol | |
| RS 23597-190 HYDROCHLORIDE Chemical Properties |
storage temp. | Sealed in dry,2-8°C | solubility | Water:36.33(Max Conc. mg/mL);100.0(Max Conc. mM) | form | Powder | color | White to off-white | Water Solubility | Soluble to 100 mM in water |
| RS 23597-190 HYDROCHLORIDE Usage And Synthesis |
Uses | RS 23597-190 Hydrochloride is a selective and competitive SR-4 and 5-HT4 receptor antagonist. | Biological Activity | A high affinity, selective competitive antagonist at 5-HT 4 receptors. | Biochem/physiol Actions | RS 23597-190 is a high affinity 5-HT4-selective antagonist with in vitro and in vivo efficacy. RS 23597-190 is a 4-amino-5-chloro-2-methoxybenzoate that antagonizes 5-HT-mediated relaxation of carbachol-contracted rat oesphageal muscularis mucosae ex vivo (pA2 = 7.5) and prevents 5-HT-induced tachycardia (tachyarrhythmia) of anaesthetized micropigs in vivo (6 mg/kg RS 23597-190 and 3-10 μ/kg 5-HT via i.v.) by targeting 5-HT4 with high affinity (pKB = 7.8) and selectivity, while exhibiting no efficacy against 5-methoxytryptamine-mediated 5-HT3 activation in guinea-pig ileum and displaying much reduced or little affinity toward 5-HT3 (pKi = 5.7/mouse NG108-15 cells and pKB <5/guinea-pig ileum), dopamine receptors (pKi <4/D1 & <3/D2), muscarinic receptors (pKi <4.5 toward M1/2/3/4), 5-HT1A & 5-HT2 (pKi <5.2). | storage | Store at RT |
| RS 23597-190 HYDROCHLORIDE Preparation Products And Raw materials |
|