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lurasidone

lurasidone Suppliers list
Company Name: Jinan Jianfeng Chemical Co., Ltd
Tel: 15562555968
Email: info@pharmachemm.com
Products Intro: Product Name:lurasidone
CAS:367514-87-2
Purity:99% Package:5KG;1KG;25kg Remarks:Pharm api
Company Name: Shochem(Shanghai) Co.,Ltd
Tel: 86-21-50800795
Email: info@shochem.com
Products Intro: Product Name:Lurasindone
CAS:367514-87-2
Purity:0.98 Package:10g, 1kg
Company Name: BOC Sciences
Tel: 1-631-619-7922
Email: inquiry@bocsci.com
Products Intro: Product Name:Lurasidone
CAS:367514-87-2
Purity:98%
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: info@dakenchem.com
Products Intro: Product Name:lurasidone
CAS:367514-87-2
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Beijing Cooperate Pharmaceutical Co.,Ltd.
Tel: +86-10-60279497 +86(0)15646567669
Email: sales01@cooperate-pharm.com
Products Intro: Product Name:Lurasidone
CAS:367514-87-2
Purity:98% Package:100G;1KG;5KG;10KG;25KG;50KG;100KG

Lastest Price from lurasidone manufacturers

  • lurasidone
  • US $1.00 / KG
  • 2019-07-06
  • CAS:367514-87-2
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 200KG
lurasidone Basic information
Drug for the treatment of schizophrenia
Product Name:lurasidone
Synonyms:Lurasindone;Lurasidone Free base;lurasidone;(3aR,4S,7R,7aS)-2-[[(1R,2R)-2-[[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]methyl]cyclohexyl]methyl]hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione;4-{[(1R,2R)-2-{[4-(2$l^{4}-thia-6-azatricyclo[5.4.0.0^{2,6}]undeca-1(11),2,4,7,9-pentaen-5-yl)piperazin-1-yl]Methyl}cyclohexyl]Methyl}-4-azatricyclo[5.2.1.0^{2,6}]deca-1(9),2(6),7-triene-3,5-dione;Lurasidone (SM13496);(3aR,4S,7R,7aS)-2-{[(1R,2R)-2-{[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]Methyl}cyclohexyl]Methyl}hexahydro-1H-4,7-Methanoisoindole-1,3(2H)-dione;urasidone
CAS:367514-87-2
MF:C28H36N4O2S
MW:492.67604
EINECS:696-042-8
Product Categories:Pharmaceutical intermediate
Mol File:367514-87-2.mol
lurasidone Structure
lurasidone Chemical Properties
Boiling point 623.4±55.0 °C(Predicted)
density 1.273
pka8.41±0.50(Predicted)
Safety Information
MSDS Information
lurasidone Usage And Synthesis
Drug for the treatment of schizophreniaLurasidone is developed by Japan's Dainippon Sumitomo Pharma which is an atypical antipsychotic,and is a classification of drug registration 3.1 class, it is suitable for the treatment of patients with schizophrenia. Its efficacy is Determined in four six weeks in adult patients with schizophrenia controlled studies. The exact mechanism of the treatment of schizophrenia, like other atypical antipsychotics ,is not very clear,and may be related to the antagonism of the dopamine D2 and serotonin 2A (5-HT2A) receptors. For the treatment of schizophrenia, a study has reported lurasidone can improve cognitive function.
October 28, 2010 ,the FDA approved lurasidone hydrochloride (lurasidone HCI) tablets once a day for the first-line treatment of patients with schizophrenia, the trade name is Latuda.
Dosage: The recommended starting dose is 40 mg/d, the effective dose range is 40~120 mg /· d, the maximum recommended dose is 80 mg /· d. It should be taken with food.
Adverse reaction: common adverse reactions are somnolence, akathisia, nausea, Parkinson's disease-like symptoms and emotional anxiety. Lurasidone has no physical dependence, less likely to cause weight gain, it does not cause glucose, lipids (lipids), it changs the period between ECG and QT.
The above information is edited by the Chemicalbook of Tian Ye.
DescriptionThe atypical antipsychotic lurasidone (also known as SM-13496) was approved in the United States in 2010 as an oral agent for the treatment of patients with schizophrenia. Lurasidone has potent affinity for D2 (Ki= 1.7 nM) and 5-HT2A (Ki= 2.0 nM) receptors and acts as an antagonist at both receptors. It is also a partial agonist at the 5-HT1A receptor and, unlike other atypical agents, is a potent antagonist at the 5-HT7 receptor; both of these activities are thought to confer beneficial cognitive properties. Lurasidone is further differentiated by its lack of affinity for muscarinic and histamine H1 receptors and its weak affinity for the 5-HT2C receptor. Antagonism at H1 and 5-HT2C receptors has been implicated in weight gain associated with atypical agents, while muscarinic receptor antagonism is associated with cognitive deficits.
OriginatorDainippon Sumitomo Pharma (Japan)
DefinitionChEBI: An N-arylpiperazine that is (3aR,4S,7R,7aS)-2-{[(1R,2R)-2-(piperazin-1-ylmethyl)cyclohexyl]methyl}hexahydro-1H-4,7-m thanoisoindole-1,3(2H)-dione in which position N4 of the piperazine ring is substituted by a 1,2-benzothiazol-3-yl group. Lurasidone is used (generally as the hydrochloride salt) as an atypical antipsychotic for the treatment of schizoph enia.
Brand nameLatuda
lurasidone Preparation Products And Raw materials
Tag:lurasidone(367514-87-2) Related Product Information
ILOPERIDONE dihydro-o-xylene 3-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]-1,2-benzothiazole (3aR,4S,7R,7aS)-2-{(1R,2S)-2-[4-(1,2-benzisothiazol-3-yl)piperazin-1-ylMethyl]cyclohexylMethyl}hexahydro-4,7-Methano-2H-isoindole-1,3-dione hydrochloride (3aR,4S,7R,7aS)-2-[[(1S,2R)-2-[[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]methyl]cyclohexyl]methyl]hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione MAVBUKOHERNHBQ-UHFFFAOYSA-N Lurasidone Impurity 24 MDYJLJKDGQUHSJ-HTWOXQOSSA-N Nsc237999 Lurasidone Impurity 2 Lurasidon hydrochloride iMpurity s,s-endo-lurasidone HCl Pregabalin Liraglutide Lurasidone hydrochloride