AMG 510 manufacturers
- AMG 510
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- $0.00 / 1KG
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2024-04-01
- CAS:2252403-56-6
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 5000
- AMG 510
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- $110.00/ kilogram
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2024-01-27
- CAS:2252403-56-6
- Min. Order: 1kilogram
- Purity: 99%
- Supply Ability: 10 tons/per week
- AMG 510
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- $0.00 / 1g
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2022-05-18
- CAS:2252403-56-6
- Min. Order: 10g
- Purity: 99.0%
- Supply Ability: 10tons
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| Product Name: | AMG 510 | | Synonyms: | 6-FLUORO-7-(2-FLUORO-6-HYDROXYPHENYL)-1-[4-METHYL-2-(PROPAN-2-YL)PYRIDIN-3-YL]-4-[(2S)-2-METHYL-4-(P;6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-4-[(2S)-2-methyl-4-(prop-2-enoyl)piperazin-1-yl]-1H,2H-pyrido[2,3-d]pyrimidin-2-one;AMG-510;AMG 510;AMG510;AMG 510;chiral AMG 510, single isomer;AMG-510，AMG510;AMG-510 atropisomer;AMG 510 USP/EP/BP | | CAS: | 2252403-56-6 | | MF: | C30H30F2N6O3 | | MW: | 560.59 | | EINECS: | | | Product Categories: | GS | | Mol File: | 2252403-56-6.mol |  |
| | AMG 510 Chemical Properties |
| Boiling point | 730.5±70.0 °C(Predicted) | | density | 1.36±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C, stored under nitrogen | | solubility | DMSO:75.0(Max Conc. mg/mL);133.78(Max Conc. mM)
Water:33.33(Max Conc. mg/mL);59.45(Max Conc. mM)
Ethanol:8.0(Max Conc. mg/mL);14.27(Max Conc. mM) | | pka | 6.52±0.35(Predicted) |
| | AMG 510 Usage And Synthesis |
| Description | AMG-510 is a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. AMG-510 irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state. AMG-510 is the first KRAS G12C inhibitor in clinical development and leads to the regression of KRAS G12C tumors.
| | use | AMG-510 is a potent, orally bioavailable, and selective KRAS G12C covalent inhibitor with anti-tumor activity.
| | Storage | -20°C, stored under nitrogen
| | In vivo | In immune-competent mice, treatment with AMG 510 resulted in a pro-inflammatory tumour microenvironment and produced durable cures alone as well as in combination with immune-checkpoint inhibitors. Cured mice rejected the growth of isogenic KRASG12D tumours, which suggests adaptive immunity against shared antigens. Reference: Nature. 2019 Nov;575(7781):217-223. https://www.nature.com/articles/s41586-019-1694-1 | | Uses | AMG-510 is a KRAS G12C inhibitor thus leading to the regression of KRAS G12C tumors as it interrupts protein signaling. | | Definition | ChEBI: Sotorasib is a pyridopyrimidine that is pyrido[2,3-d]pyrimidin-2(1H)-one substituted by 4-methyl-2-(propan-2-yl)pyridin-3-yl, (2S)-2-methyl-4-(prop-2-enoyl)piperazin-1-yl, fluoro and 2-fluoro-6-hydroxyphenyl groups at positions 1, 4, 6 and 7, respectively. It is approved for the treatment of patients with non-small cell lung cancer having KRAS(G12C) mutations. It has a role as an antineoplastic agent. It is a member of acrylamides, a N-acylpiperazine, a pyridopyrimidine, a member of monofluorobenzenes, a member of methylpyridines, a tertiary carboxamide, a tertiary amino compound and a member of phenols. | | in vitro | It was examined whether AMG510 has an antitumor effect on the CACO-2 (human colorectal cancer) cells into which the KRAS G12C (Kirsten rat sarcoma 2 viral oncogene homolog mutation) gene was introduced. The results showed that there was a clear concentration dependent RPR (relative proliferation ratio) decrease and that AMG 510 selectively inhibited KRAS G12C in colon cancer cells in vitro (Fig. 4A). Reference: Mol Clin Oncol. 2021 Jul;15(1):148. | | storage | Store at -20°C |
| | AMG 510 Preparation Products And Raw materials |
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