| Company Name: |
BOC Sciences
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| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:CAY10464
CAS:688348-37-0
Purity:>=98% Remarks:Reach out to us for more information about custom solutions.
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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sales@chemegen.com |
| Products Intro: |
Product Name:CAY10464
CAS:688348-37-0
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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CAY10464 manufacturers
- CAY10464
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- $40.00 / 5mg
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2025-11-09
- CAS:688348-37-0
- Min. Order:
- Purity: 99.96%
- Supply Ability: 10g
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| | CAY10464 Basic information |
| Product Name: | CAY10464 | | Synonyms: | CAY10464;1,3-dichloro-5-[(1E)-2-(4-methoxyphenyl)ethenyl]-benzene;CAY10464 Exclusive;1,3-dichloro-5-[(E)-2-(4-methoxyphenyl)ethenyl]benzene;Benzene, 1,3-dichloro-5-[(1E)-2-(4-methoxyphenyl)ethenyl]- | | CAS: | 688348-37-0 | | MF: | C15H12Cl2O | | MW: | 279.16 | | EINECS: | | | Product Categories: | | | Mol File: | 688348-37-0.mol |  |
| | CAY10464 Chemical Properties |
| Boiling point | 409.3±45.0 °C(Predicted) | | density | 1.265±0.06 g/cm3(Predicted) | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2)(1:1): .5 mg/ml; Ethanol: 10 mg/ml | | form | A crystalline solid | | color | White to off-white |
| | CAY10464 Usage And Synthesis |
| Description | The aryl hydrocarbon receptor (AhR) is a ligand-dependent intracellular transcription factor whose ligands include some of the most infamous xenobiotics, including dioxin (TCDD, 2,3,7,8-tetrachlorodibenzoparadioxin), benzo[a]pyrene, and numerous polyaromatic hydrocarbons from soot particles and coal tar. CAY10464 is a potent and selective AhR antagonist, with a Ki of 1.4 nM when tested in rabbit liver cytosol preparations. It is inactive as an estrogen receptor ligands even at 100 μM. | | Uses | CAY10464 (AHR antagonist 7; compound 4j) is a selective and high-affinity aryl hydrocarbon receptor (AhR) antagonist with a Ki of 1.4 nM[1]. | | References | [1] Philippe de Medina, et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. J Med Chem. 2005 Jan 13;48(1):287-91. DOI:10.1021/jm0498194
[2] Emad Naem,et al. Inhibition of apolipoprotein A-I gene by the aryl hydrocarbon receptor: a potential mechanism for smoking-associated hypoalphalipoproteinemia. Life Sci. 2012 Jul 26;91(1-2):64-9. DOI:10.1016/j.lfs.2012.06.002 |
| | CAY10464 Preparation Products And Raw materials |
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