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Diosgenin

Diosgenin Suppliers list
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-66670886
Email: info@dakenchem.com
Products Intro: Product Name:Diosgenin
CAS:512-04-9
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: Product Name:Diosgenin
CAS:512-04-9
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: Shanghai Yingrui Biopharma Co., Ltd.
Tel: +86-21-33585366 E-mail:sales03@shyrchem.com
Email: sales03@shyrchem.com
Products Intro: Product Name:Diosgenin
CAS:512-04-9
Purity:99% Package:100g;500g;1kg;25kg...
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +86 21 5161 9050/ 5187 7795
Email: ivan@atkchemical.com
Products Intro: CAS:512-04-9
Purity:98% HPLC Package:5G;10G;25G;50G;100G;250G;1KG
Company Name: Shanghai Zheyan Biotech Co., Ltd.
Tel: 18017610038
Email: zheyansh@163.com
Products Intro: Product Name:Diosgenin
CAS:512-04-9
Purity:HPLC>=98% Package:20mg

Lastest Price from Diosgenin manufacturers

  • Diosgenin 512-04-9
  • US $15.00 / g
  • 2021-09-26
  • CAS:512-04-9
  • Min. Order: 1g
  • Purity: ≥98%
  • Supply Ability: 1000.00 kgs
  • Diosgenin
  • US $10.00 / KG
  • 2021-08-13
  • CAS:512-04-9
  • Min. Order: 10g
  • Purity: 99
  • Supply Ability: 50 Ton/Tons per Month
  • diosgenin
  • US $25.00 / KG
  • 2021-07-31
  • CAS:512-04-9
  • Min. Order: 1KG
  • Purity: 6%98%
  • Supply Ability: 100kg
Diosgenin Basic information
Product Name:Diosgenin
Synonyms:Diosgemom;DIOCTYLMALONATE;DIOSGENIN (3B-HYDROXY-5A-SPIROSCENE);20F,22F-Spirosten-3-ol;22alpha-Spirost-5-en-3beta-ol;25d-Spirost-5-en-3b-ol;5-22-Spirosten-3-ol;5-25D-Spirosten-3-ol
CAS:512-04-9
MF:C27H42O3
MW:414.63
EINECS:208-134-3
Product Categories:Plant extracts;Herb extract;Biochemistry;Steroids;Steroids (Others);The group of Dioscin;APIs;Intermediates & Fine Chemicals;Pharmaceuticals;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Pharmaceutical Intermediates;FINE Chemical & INTERMEDIATES;API;reference substance;Plant extract;Inhibitors
Mol File:512-04-9.mol
Diosgenin Structure
Diosgenin Chemical Properties
Melting point 205-208°C
Boiling point 473.46°C (rough estimate)
alpha D25 -129° (c = 1.4 in CHCl3)
density 1.0483 (rough estimate)
refractive index 1.4700 (estimate)
storage temp. 2-8°C
solubility chloroform: 20 mg/mL, clear, slightly yellow
pka15.02±0.70(Predicted)
Water Solubility Soluble in chloroform (50 mg/ml), ethanol (83 mg/ml at 25°C), water (<1 mg/ml at 25°C), DMSO (<1 mg/ml at 25°C), and methanol.
Merck 14,3295
BRN 94582
CAS DataBase Reference512-04-9(CAS DataBase Reference)
NIST Chemistry ReferenceDiosgenin(512-04-9)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36/37-24/25
WGK Germany 2
RTECS WH1450000
HS Code 29329990
MSDS Information
ProviderLanguage
(25R)-Spirost-5-en-3beta-ol English
SigmaAldrich English
Diosgenin Usage And Synthesis
Chemical PropertiesWhite to Off-White Dolid
Usesantiinflammatory, estrogen
UsesAglicone of saponin dioscin. Diosgenin exists in some food supplements and herbal medicines and lowers plasma cholesterol by increasing fecal cholesterol excretion. e and Progesterone.
Usespregnenolone and progesterone precursor
Anticancer ResearchIt is a steroidal saponin and legumes and yams are the rich sources of it. It is a notoriousprecursor of several synthetic steroidal drugs. It suppresses growth of cells andinduces apoptosis in human osteosarcoma, colon cancer, and leukemia. Its anticancermechanism is by arresting the cell cycle, disrupting the calcium homeostasis,activating p53, releasing apoptosis inducing factors, and modulating caspase-3activity. It suppresses NF-κB activation induced by TNF as a result of DNA binding,IκBα kinase activation, degradation, phosphorylation, p65 nuclear translocation,and phosphorylation. It suppresses proliferation and invasion and induces apoptosisby downregulation of cFLIP, cyclin-D1, TRAF1, COX-2, c-myc, Bfl-1/A1, BclxL,IAP1, Bcl-2, and MMP-9 (Aggarwal et al. 2008; Raju and Mehta 2008).
Purification MethodsCrystallise diosgenin from acetone, and chromatograph it on Al2O3 and elute with *C6H6/Et2O (9:1), then recrystallise it from MeOH. Its solubility is ~4% in H2O and 5% in CHCl3. The acetate crystallises from AcOH with m 198o; and has [] D 20 -119o (pyridine). [Marker et al. J Am Chem Soc 65 1199 1943. Mazur et al. J Am Chem Soc 82 5889 1960, Beilstein 19 IV 862.]
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