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Icariin

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CAS:489-32-7
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Icariin manufacturers

  • Lcariin
  • $1.00 / 10g
  • 2022-12-07
  • CAS:489-32-7
  • Min. Order: 10g
  • Purity: 98% HPLC
  • Supply Ability: 1000kg
  • Icariin
  • $0.00 / 1KG
  • 2022-12-07
  • CAS:489-32-7
  • Min. Order: 100g
  • Purity: 98%+
  • Supply Ability: 100kg
  • Epimedium Extract
  • $0.00 / 1kg
  • 2022-12-06
  • CAS:489-32-7
  • Min. Order: 1kg
  • Purity: 98%
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Icariin Basic information
Applications Description References
Product Name:Icariin
Synonyms:Epimedium herb Ext;Epimedium P.E;Icariin, froM EpiMediuM davidii Franch;Icariin Min 90%;EpiMediuM Leaf Extract, Icariin 10% by HPLC;Icariin Min 90% SynonyMs 3-[(6-Deoxy-alpha-L-Mannopyranosyl)oxy]-7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(4-Methoxyphenyl)-8-(3-Methyl-2-buten-1-yl)-4H-1-benzopyran-4-one;Epimedium grandiflorum;4′-O-methyl-8-γ,γ-dimethylallylkaempferol-3-rhamnoside-7-glucoside
CAS:489-32-7
MF:C33H40O15
MW:676.66
EINECS:610-440-0
Product Categories:Plant extracts;chemical reagent;Functional Products;plant extract;Nutritional Ingredients;pharmaceutical intermediate;Natural Plant Extract;The group of Epimedii;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Standardized plant extract;Inhibitors;API;Flavones
Mol File:489-32-7.mol
Icariin Structure
Icariin Chemical Properties
Melting point 223-225 ºC
alpha D15 -87.09° (in pyridine)
Boiling point 948.5±65.0 °C(Predicted)
density 1.55
RTECS DJ2980500
storage temp. 2-8°C
solubility DMSO: soluble50mg/mL, clear, colorless to dark yellow
form Powder
pka5.90±0.40(Predicted)
color light yellow to yellow
λmax350nm(MeOH)(lit.)
Merck 14,3617
Stability:Light Sensitive
InChIKeyTZJALUIVHRYQQB-XLRXWWTNSA-N
Safety Information
Safety Statements 24/25
WGK Germany 3
HS Code 29389090
MSDS Information
Icariin Usage And Synthesis
Applications

Icariin inhibits the ROS-dependent JNK and p38 pathways.

DescriptionIcariin is one of the major flavonoids of the herb Epimedium, which has long been used in Tranditional Chinese Medicine to treat bone fracture and prevent osteoporosis. Research has shown that icariin should be an effective component for the bone-strengthening activity of the herb Epimedium, and one of the possible mechanisms for this activity is to stimulate the proliferation and enhance the osteogenic differentiation of marrow stromal cells. Icariin is reported to prevent and treat sexual dysfunction related diseases and improve the use of vasoconstriction. Icariin is used to prepare angiotensin converting enzyme inhibitor medicines, which can be used to treat hypertension-complicated coronary diseases.
References[1] K. M. Chen, B. F. Ge, H. P. Ma, X. Y. Liu, M. H. Bai, Y, Wang (2005) Icariin, a flavonoid from the herb Epimedium enhances the osteogenic differentiation of rat primary bone marrow stromal cells, 60, 939-942
[2] Patent CN 1199647C “Application of icariin in preparation of medicine for preventing and treating sexual dysfunction”
[3] Patent CN 104739851 A “New application of icariin, or icariin derivatives or icariin salt”
Chemical Properties

Light yellow to yellow solid

Useshepatoprotective
UsesIcariin has been used:
  • in the preparation of topical treatment to determine its effects on the improvement of cutaneous wound healing in rats
  • to test its analgesic effects on lower back pain (LBP) in rats
  • as a potential treatment in osteoporosis condition in rats
  • to study its effects on palmitate (PA)-induced insulin resistance in skeletal muscle C2C12 myotubes
  • as a neuroprotective agent to study its effects on amyloid-β (Aβ)-induced neuronal insulin resistance in human neuroblastoma SK-N-MC cells

UsesIcariin has been used as a test material to investigate its, in vitro effect in promoting mouse hair follicle growth, which is assessed by vibrissae hair follicle (VHF) organ-culture model.
General DescriptionIcariin is a prenylated flavonol and the major bioactive compound found in Epimedium herb.
Biological Activityicariin exhibits inhibitory effects on cgmp-specific phosphodiesterase pde5 and camp-specific phosphodiesterase pde4 activities. phosphodiesterase (pde) is a crucial regulator of camp/pka signaling. pdes are encoded by 21 genes which can be sdivided into 11 families according to the substrate specificities and subcellular localization. pdes are widely expressed in neurons. pde5 has been implicated in regulating some physiological processes such as smooth muscle relaxation and neuronal survival. pde4 has been associated with the darpp-32 signaling pathway and dopaminergic neurotransmission [1].
Biochem/physiol ActionsIcariin is a potent neuroprotective agent in neurodegenerative disorders and other disorders affecting the nervous system. It elicits anti-aging properties in unfertilized oocytes against age-related damage. Icariin exerts anti-inflammatory and antifibrotic properties aiding protection in chronic kidney disease (CKD)-associated renal fibrosis in mouse model. It also serves as an excellent antidiabetic and anti-atherosclerotic agent. Icariin is an excellent anti-cancer agent.
in vitroicariin inhibited the activity of pde5 and pde4 in a dose- andconcentration-dependent manner. the ic50of icariin on pde5 was 0.43 μm and the ic50 on pde4 was 73.50 μm. icariin showed a selective inhibitory effect on cgmp-specific pde5 compared to camp-specific pde4 [2].icariincould also enhance the osteogenic differentiation of rat primary bone marrow stromal cells [3].
in vivoin castrated rats, a 4-week oral administration of icariinat 1 mg/kg/day and 5 mg/kg/day improved the erectile function and increased nnos and inos expression [4].icariin also showed its effect on stimulating angiogenesis in human endothelial cells [5].
referencesnishi a, kuroiwa m, miller d b, et al. distinct roles of pde4 and pde10a in the regulation of camp/pka signaling in the striatum[j]. the journal of neuroscience, 2008, 28(42): 10460-10471.xin z c, kim e k, lin c s, et al. effects of icariin on cgmp-specific pde5 and camp-specific pde4 activities[j]. asian journal of andrology, 2003, 5(1): 15-18.chen k m, ge b f, ma h p, et al. icariin, a flavonoid from the herb epimedium enhances the osteogenic differentiation of rat primary bone marrow stromal cells[j]. die pharmazie-an international journal of pharmaceutical sciences, 2005, 60(12): 939-942.liu w j, xin z c, xin h, et al. effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats[j]. asian journal of andrology, 2005, 7(4): 381-388.chung b h, kim j d, kim c k, et al. icariin stimulates angiogenesis by activating the mek/erk-and pi3k/akt/enos-dependent signal pathways in human endothelial cells[j]. biochemical and biophysical research communications, 2008, 376(2): 404-408.
Tag:Icariin(489-32-7) Related Product Information
NOR-ICARITIN Anhydroicaritin Icariside I epimedoside A Apigenin Ginkgo biloba extract Motherwort Herb P.E Epimedin A Epimedium Extract Matrine 4H-1-Benzopyran-4-one, 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-8-(3-hydroxy-3-methylbutyl)-2-(4-methoxyphenyl)- Epimedium polysaccharide Icaritin D-(-)-Salicin Resveratrol 8-METHYLFLAVONE 2'-HYDROXY-5'-METHYLCHALCONE 3',5'-Dimethoxytricetin 7-O-β-D-glucopypranoside