- 2,4,6-Trichloroaniline
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- $10.70 / 1KG
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2024-09-19
- CAS:634-93-5
- Min. Order: 10KG
- Purity: 99%
- Supply Ability: 10000kg
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| Product Name: | 2,4,6-Trichloroaniline | | Synonyms: | 2,4,6-Trichloroaniline, 98.5% 100GR;1-Amino-2，4，6-trichlorobenzene;2,4,6-TRICHLOROANILINE;2,4,6-trichloraniline;2,4,6-trichloro-anilin;2,4,6-trichloro-benzenamin;Aniline, 2,4,6-trichloro-;aniline,2,4,6-trichloro- | | CAS: | 634-93-5 | | MF: | C6H4Cl3N | | MW: | 196.46 | | EINECS: | 211-219-8 | | Product Categories: | Alpha sort;Amines;AromaticsPesticides&Metabolites;Chemical Class;Q-ZAlphabetic;TP - TZ | | Mol File: | 634-93-5.mol |  |
| | 2,4,6-Trichloroaniline Chemical Properties |
| Melting point | 73-75 °C (lit.) | | Boiling point | 262 °C (lit.) | | density | 1.6807 (rough estimate) | | vapor pressure | 0-0.631Pa at 25℃ | | refractive index | 1.6300 (estimate) | | Fp | 262°C | | storage temp. | Storage temperature: no restrictions. | | solubility | 0.039g/l slightly soluble | | pka | 0.07±0.10(Predicted) | | color | Needles or liquid from pet ether | | Water Solubility | <0.1 g/100 mL at 21.5 ºC | | BRN | 879568 | | Stability: | Stable, but may be light or air sensitive. Incompatible with acids, acid chlorides, acid anhydrides, chloroformates, strong oxidizing agents. | | InChIKey | NATVSFWWYVJTAZ-UHFFFAOYSA-N | | LogP | 3.648-3.69 at 25℃ | | CAS DataBase Reference | 634-93-5(CAS DataBase Reference) | | NIST Chemistry Reference | Benzenamine, 2,4,6-trichloro-(634-93-5) | | EPA Substance Registry System | 2,4,6-Trichloroaniline (634-93-5) |
| | 2,4,6-Trichloroaniline Usage And Synthesis |
| Genotoxicity | Limited information is available regarding the potential genotoxicity of 2,4,6-trichloroaniline. 2,4,6-Trichloroaniline did not induce mutations in Salmonella typhimurium strains TA98, TA100, or TA1537 in the presence or absence of metabolic activation in plate-incorporation assays; microsomal-suspension assays using the same strains and metabolic-activation preparations were also negative. However, using the preincubation method, 2,4,6-trichloroaniline tested positive for mutagenicity in Salmonella and Escherichia coli (strains not specified). 2,4,6-Trichloroaniline tested negative in the Salmonella umu (SOS response) assay and failed to induce DNA repair in rat hepatocytes. In vivo, 2,4,6-trichloroaniline was mutagenic in the wing spot test in Drosophila. Rats treated orally with 2,4,6-trichloroaniline at 40 mg/kg-day (but not 0.4 or 4 mg/kg-day) for 6 months showed a small but statistically significant increase (p < 0.05) in the number of bone marrow cells containing chromosomal aberrations when compared with controls (1.6% vs. 0.4%, respectively); however, this study did not provide any study design details.
| | Description |
Trichloroaniline is particularly important as a chemical intermediate in manufacturing many benzene derivatives and other organic compounds. For instance, 2,4,6-trichloroaniline is an essential precursor of 1,3,5-trichlorobenzene. The latter has been extensively studied and developed for insecticides and fungicides. It, in turn, is a precursor of trichlorodinitrobenzene, which is especially important in combatting crop diseases and is an intermediate for dyestuffs. In military applications, 2,4,6-trichloroaniline is utilized for the preparation of insensitive energetic material that is employed in several Navy weapons systems. The synthesis of 2,4,6-trichloroaniline has almost invariably been accomplished by chlorinating aniline with chlorine or sulfuryl chloride.
| | Chemical Properties | fine purple fibres | | Uses | 2,4,6-trichloroaniline is important as an intermediate in the manufacture of benzene derivatives, including 1,3,5-trichlorobenzene and is useful in the formation of fungicides, mono-azo dyestuffs, and the preparation of hexachlorodiphenyl urea.
Tetrachloronitrobenzene was prepared from 2:4:6-trichloroaniline,which was converted by a Sandmeyer reaction into 1:2:3:5- tetrachlorobenzene. | | Preparation | 2,4,6-Trichloroaniline can be prepared by reaction of dry aniline with chlorine gas while in a anhydrous solution of carbon tetrachloride. 2,4,6-Trichloroaniline precipitates from solution as a white solid. If water is introduced to the solution the white material will polymerize to form aniline black.
Process for the preparation of 2,4,6-trichloroaniline | | General Description | Long needles or fine, light purple fibers. | | Air & Water Reactions | 2,4,6-Trichloroaniline may be sensitive to exposure to light and air. Insoluble in water. | | Reactivity Profile | 2,4,6-Trichloroaniline is incompatible with acids, acid chlorides, acid anhydrides, chloroformates, and strong oxidizing agents. . | | Fire Hazard | Flash point data for 2,4,6-Trichloroaniline are not available. 2,4,6-Trichloroaniline is probably combustible. | | Safety Profile | Moderately toxic by ingestion.Irritant. Questionable carcinogen with experimentalcarcinogenic data. Mutation data reported. When heatedto decomposition it emits very toxic fumes of Clí andNOx. | | Purification Methods | Crystallise the aniline from ligroin. The benzoyl derivative has m 174o (from EtOH). [Beilstein 12 H 627, 12 IV 1281.] |
| | 2,4,6-Trichloroaniline Preparation Products And Raw materials |
| Raw materials | Aniline | | Preparation Products | 1,3,5-Trichlorobenzene-->4-Amino-3,5-dichloroacetophenone-->2,2',4,4',6,6'-HEXACHLOROBIPHENYL-->2,4,6-Trichloroiodobenzene-->1-BROMO-2,4,6-TRICHLOROBENZENE-->2,2',3,4,4',5,6,6'-OCTACHLOROBIPHENYL-->1,2,3,5-Tetrachlorobenzene-->2-azido-1,3,5-trichlorobenzene |
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