托麦汀
中文名称 | 托麦汀 |
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中文同义词 | 托美汀(托美汀酸);甲苯酰吡咯乙酸;痛灭定;托麦汀;托美汀;2-[1-甲基-5-(4-甲基苯甲酰)吡咯-2-基]乙酸;托美汀溶液,100PPM;托美汀(托麦汀) |
英文名称 | Tolmetin |
英文同义词 | 1-Methyl-5-p-toluoylpyrrole-2-acetic acid;5-[(p-Tolyl)carbonyl]-1-methylpyrrole-2-acetic acid;McN 2559;1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetic acid;1-Methyl-5-(p-toluoyl)-1H-pyrrole-2-acetic acid;C07149;2-(1-Methyl-5-(4-Methylbenzoyl)-1H-pyrrol-2-yl)acetic acid;2-{1-Methyl-5-[(4-Methylphenyl)carbonyl]-1H-pyrrol-2-yl}acetic acid |
CAS号 | 26171-23-3 |
分子式 | C15H15NO3 |
分子量 | 257.28 |
EINECS号 | 247-497-2 |
相关类别 | 医药中间体;小分子抑制剂;其他兽药标准品;小分子抑制剂,天然产物;化工中间体;医药原料;Inhibitors;API;API intermediates |
Mol文件 | 26171-23-3.mol |
结构式 |
托麦汀 性质
熔点 | 156 °C |
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沸点 | 400.53°C (rough estimate) |
密度 | 1.1391 (rough estimate) |
折射率 | 1.5200 (estimate) |
储存条件 | 2-8°C |
溶解度 | 可溶于氯仿(少许)、甲醇(少许) |
形态 | 固体 |
酸度系数(pKa) | pKa 3.5(H2O t undefined I undefined) (Uncertain) |
颜色 | 灰白色至浅黄色 |
水溶解性 | 222 mg/L |
NIST化学物质信息 | Tolmetin(26171-23-3) |
EPA化学物质信息 | 1H-Pyrrole-2-acetic acid, 1-methyl-5-(4-methylbenzoyl)- (26171-23-3) |
Human COX-1 0.35 μM (IC 50 ) |
Human COX-2 0.82 μM (IC 50 ) |
Tolmetin (0.25 mM) does not attenuate lipid peroxidation in rat brain homogenate. Tolmetin (0.25, 0.5, 0.75, 1 mM) shows radical scavenging properties but without superoxide anion generation in rat brain homogenat.
Tolmetin (0.001-100 μM) shows anticancer activity againts HT-29 colon cancer cell line in a dose-dependent manner.
Tolmetin (0-100 μM) shows no effect on osteoblast growth.
Tolmetin (30,100 mg/kg; gavage; single dose or twice daily for 3 and 14 days) shows maximal ulcerogenic effect 4 h after the single dose, while potently decreases after 3 and 14 days of repeated administration in male Wistar rats weighing 180-200 g. Tolmetin causes gastric lesions in 100 mg/kg.
Tolmetin (5 mg/kg twice a day for 5 days) pre-treatment considerably attenuates quinolinic acid (QA)-induced neurotoxicity.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/25 | HY-B1799 | Tolmetin | 5 mg | 230元 | |
2024/01/25 | HY-B1799 | 托麦汀 Tolmetin | 26171-23-3 | 10mM * 1mLin DMSO | 253元 |