(+)-Fenfluramine hydrochloride

(+)-Fenfluramine hydrochloride Suppliers list
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 86-18871470254
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Products Intro: Product Name:(S)-fenfluramine hydrochloride
CAS:3239-45-0
Purity:0.99 Package:5KG;1KG
Company Name: BOC Sciences
Tel: 1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:Dexfenfluramine hydroChloride
CAS:3239-45-0
Purity:95%
Company Name: HENAN BON INDUSTRIAL CO.,LTD
Tel: 0371-55170695
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Products Intro: CAS:3239-45-0
Purity:0.99 Package:25KG;5KG;1KG;500G
Company Name: CONIER CHEM AND PHARMA LIMITED
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Products Intro: Product Name:dexfenfluramine hydrochloride
CAS:3239-45-0
Purity:99% Package:1kg
Company Name: career henan chemical co
Tel: 0086-371-86658258 13203830695
Email: factory@coreychem.com
Products Intro: Product Name:(+)-Fenfluramine hydrochloride
CAS:3239-45-0
Purity:98%HPLC Package:1KG;1USD

(+)-Fenfluramine hydrochloride manufacturers

(+)-Fenfluramine hydrochloride Basic information
Product Name:(+)-Fenfluramine hydrochloride
Synonyms:(S)-N-ethyl-alpha-methyl-m-(trifluoromethyl)phenethylamine hydrochloride;Dexfenfluramine hydrochloride;Dexfenfluramine hydrochloride, (+)-N-Ethyl-α-methyl-m-[trifluoromethyl]phenethylamine hydrochloride;ethyl-[(1S)-1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]amine hydrochloride;(S)-(+)-Fenfluramine Hydrochloride;(S)-N-Ethyl-α-methyl-3-(trifluoromethyl)benzeneethanaminehydrochloride;(aS)-N-Ethyl-α-methyl-3-(trifluoromethyl)benzeneethanamine Hydrochloride;S-Fenfluramine HCl
CAS:3239-45-0
MF:C12H17ClF3N
MW:267.7182896
EINECS:221-806-0
Product Categories:Intermediates & Fine Chemicals;Pharmaceuticals;Amines;Aromatics
Mol File:3239-45-0.mol
(+)-Fenfluramine hydrochloride Structure
(+)-Fenfluramine hydrochloride Chemical Properties
Melting point 159-163°C
storage temp. Desiccate at RT
solubility H2O: soluble10mg/mL
form powder
color white to off-white
Safety Information
Hazard Codes T
Risk Statements 23/24/25
Safety Statements 22-36/37/39-45
RIDADR UN 2811
WGK Germany 3
RTECS SH6824000
HazardClass 6.1(b)
PackingGroup III
MSDS Information
(+)-Fenfluramine hydrochloride Usage And Synthesis
DescriptionRedux, having been already launched in Europe, was marketed in Canada and the US for obesity. The (+)-isomer of fenfluramine is obtained by resolution using d-camphoric acid and ultimate conversion to the HCl salt. The levo-isomer has significant effects on dopaminerigic neurotransmission, while the dextro-isomer has a greater anorectic effect because it is more selective on serotonin as a 5-HT agonist with no dopaminergic or noradenergic activity. Redux inhibits the presynaptic release of serotonin, is a reuptake inhibitor, a 5-HT1B, receptor agonist, and a postsynaptic 5-HT2C receptor agonist . A dietary reduction in fat intake was thought to proceed via a CCK A-type receptor agonist activity. Due to the side effects of primary pulmonary hypertension, brain serotonin neurotoxicity and valvular heart disease, Redux was withdrawn world wide.
Chemical PropertiesWhite Crystalline Powder
OriginatorServier (France)
UsesControlled substance. Anorexic
DefinitionChEBI: The hydrochloride salt of (S)-fenfluramine. It stimulates the release of serotonin and selectively inhibits its reuptake, but unlike the racemate it does not possess catecholamine agonist activity. It was formerly given by mouth in the tre tment of obesity, but, like the racemate, was withdrawn wolrdwide following reports of valvular heart defects.
Brand nameRedux (Interneuron).
Biological ActivityIndirectly agonizes serotonin receptors via inhibition of 5-HT re-uptake and stimulation of 5-HT release. Anorectic agent; decreases growth hormone, insulin, leptin, fat mass, lean mass and increases ghrelin in diet-switched diet-induced obese mice.
(+)-Fenfluramine hydrochloride Preparation Products And Raw materials
Tag:(+)-Fenfluramine hydrochloride(3239-45-0) Related Product Information
Iron-dextran 2-PhenylethylaMine 3-(TRIFLUOROMETHYL)PHENETHYLAMINE FENFLURAMINE R(-)-FENFLURAMINE HYDROCHLORIDE LESS ACT IVE ENANTIOME D-Fenfluramine hydrochloride (+/-)-FENFLURAMINE HYDROCHLORIDE,FENFLURAMINE HYDROCHLORIDE,FENFLURAMINE HYDROCHLORIDE MM(CRM STANDARD) fenfluramine hydrochloride*methanol solution,FENFLURAMINE HYDROCHLORIDE,(+/-)-FENFLURAMINE HYDROCHLORIDE,FENFLURAMINE HYDROCHLORIDE--DEA*SCHEDULE IV ITEM R(-)-FENFLURAMINE HYDROCHLORIDE (+)-FENFLURAMINE HYDROCHLORIDE,(+)-fenfluramine hydrochloride--dea*schedule iv I