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Fenfluramine hydrochloride

Fenfluramine hydrochloride Suppliers list
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Products Intro: Product Name:Fenfluramine hydrochloride
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Fenfluramine hydrochloride manufacturers

  • Fenfluramine hydrochloride
  • $15.00-10.00 / KG
  • 2021-08-12
  • CAS:404-82-0
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
Fenfluramine hydrochloride Basic information
Product Name:Fenfluramine hydrochloride
Synonyms:FENFLURAMINE HYDROCHLORIDE MM(CRM STANDARD);N-Ethyl-a-methyl-3-(trifluoromethyl)benzeneethanamine Hydrochloride;(+)-n-ethyl-α-methyl-m-[trifluoromethyl]phenethylamine hydrochloride;BenzeneethanaMine,N-ethyl-a-Methyl-3-(trifluoroMethyl)-,hydrochloride (1:1);(+)-N-Ethyl-α-methyl-m-[trifluoromethyl]phenethylamine;n-ethyl-1-[3-(trifluoromethyl)phenyl]-propan-2-amine;N-ETHYL-ALPHA-METHYL-3-(TRIFLUOROMETHYL)PHENETHYLAMINE HYDROCHLORIDE;N-ETHYL-ALPHA-METHYL-M-(TRIFLUOROMETHYL)PHENETHYLAMINE HYDROCHLORIDE
Product Categories:Intermediates & Fine Chemicals;Pharmaceuticals;Amines;Aromatics
Mol File:404-82-0.mol
Fenfluramine hydrochloride Structure
Fenfluramine hydrochloride Chemical Properties
Melting point 1660C
Boiling point 108-112 °C(Press: 12 Torr)
storage temp. 2-8°C
form A solid
CAS DataBase Reference404-82-0(CAS DataBase Reference)
Safety Information
Hazard Codes T
Risk Statements 25-23/24/25
Safety Statements 7-16-36/37-45-36/37/39-22
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS DA0295500
HazardClass 6.1(b)
PackingGroup III
ToxicityLD50 oral in rabbit: 50mg/kg
MSDS Information
SigmaAldrich English
Fenfluramine hydrochloride Usage And Synthesis
Chemical PropertiesCrystalline Solid
UsesControlled substance. Anorexic
DefinitionChEBI: The hydrochloride salt of fenfluramine. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine hydrochloride was used for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Brand namePondimin (Robins).
General DescriptionFenfluramine hydrochloride, (±)N-ethyl- -methyl-m-(trifluoromethyl)phenethylamine hydrochloride (Pondimin), isunique in this group of drugs, in that it tends to produce sedationrather than excitation. Effects are said to be mediatedprincipally by central serotoninergic, rather than central noradrenergic,mechanisms. In large doses in experimental animals,the drug is a serotonin neurotoxin.It was withdrawnfrom human use after reports of heart valve damage and pulmonaryhypertension. From its structure, more apolar or hydrophobiccharacter than amphetamine, tropism for serotoninergicneurons would be expected. Likewise, thestructure suggests an indirect mechanism. If an indirectmechanism were operative, then all postsynaptic 5-HT receptors could be activated. Evidence from several studies indicatesthat the 5-HT1B and the 5-HT2C receptors are mostresponsible for the satiety effects of 5-HT. 5-HT may alsoinfluence the type of food selected (e.g., lower-fat food intake).The(+) isomer, dexfenfluramine (Redux), has agreater tropism for 5-HT systems than the racemic mixture.It, too, was withdrawn because of toxicity.
Safety ProfilePoison by ingestion, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: mydriasis, change in motor activity, nausea. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits very toxic fumes of F-, NOx, and HCl
Fenfluramine hydrochloride Preparation Products And Raw materials
Preparation ProductsFENFLURAMINE
Tag:Fenfluramine hydrochloride(404-82-0) Related Product Information
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