Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-[(2-oxo[1(2H),2'-bipyridin]-3-yl)amino]- manufacturers
- TAK 279
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2026-07-22
- CAS:2272904-53-5
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1000kg
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| | Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-[(2-oxo[1(2H),2'-bipyridin]-3-yl)amino]- Basic information |
| Product Name: | Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-[(2-oxo[1(2H),2'-bipyridin]-3-yl)amino]- | | Synonyms: | Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-[(2-oxo[1(2H),2'-bipyridin]-3-yl)amino]-;NDI-034858(Zasocitinib);Zasocitinib，NDI-034858，TAK 279;N-((1R,2R)-2-methoxycyclobutyl)-7-(methylamino)-5-((2-oxo-2H-[1,2'-bipyridin]-3-yl)amino)pyrazolo[1,5-a]pyrimidine-3-carboxamide;N-[(1R,2R)-2-Methoxycyclobutyl]-7-(methylamino)-5-[(2-oxo-2H-[1,2’-bipyridin]-3-yl)amino]pyrazolo[1,5-a]pyrimidine-3-carboxamide;TAK 279;N-((1R,2R)-2-Methoxy-cyclobutyl)-7-(methylamino)-5-((2-oxo-2H-[1,2'-bipyridin]-3-yl)amino)-1H-pyrazolo[1,5-a]pyrimidine-3-carboxamide;Zasocitinib,2272904-53-5,Pharmaceutical Chemicals | | CAS: | 2272904-53-5 | | MF: | C23H24N8O3 | | MW: | 460.49 | | EINECS: | | | Product Categories: | | | Mol File: | 2272904-53-5.mol | ![Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-[(2-oxo[1(2H),2'-bipyridin]-3-yl)amino]- Structure](CAS/20210305/GIF/2272904-53-5.gif) |
| | Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-[(2-oxo[1(2H),2'-bipyridin]-3-yl)amino]- Chemical Properties |
| density | 1.49±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Acetonitrile: Soluble
DMSO: Soluble | | form | Solid | | pka | 10.37±0.40(Predicted) | | color | Off-white to light yellow | | InChIKey | BWINBHTTZLVXGT-NVXWUHKLSA-N | | SMILES | C12=C(C(N[C@@H]3CC[C@H]3OC)=O)C=NN1C(NC)=CC(NC1=CC=CN(C3=NC=CC=C3)C1=O)=N2 |
| | Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-[(2-oxo[1(2H),2'-bipyridin]-3-yl)amino]- Usage And Synthesis |
| Uses | Zasocitinib (NDI-034858) is a TYK2 inhibitor, target TYK2 JH2 domain with binding constant Kd of <200 pM[1]. | | References | [1] Masse, Craig E, et al. Pyrazolopyrimidines as TYK2 inhibitors and their preparation: World Intellectual Property Organization, WO2019023468. 2019-01-31.
[2] SILVANA LEIT, CRAIG E. MASSE Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279[J]. Journal of Medicinal Chemistry, 2023, 66 15: 10473-10496. DOI: 10.1021/acs.jmedchem.3c00600 |
| | Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-[(2-oxo[1(2H),2'-bipyridin]-3-yl)amino]- Preparation Products And Raw materials |
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