朱砂精酸
中文名称 | 朱砂精酸 |
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中文同义词 | 朱砂精酸;化合物 T22669 |
英文名称 | cinnabarinic acid |
英文同义词 | cinnabarinic acid;2-Amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid;Cinnabaric Acid;3H-Phenoxazine-1,9-dicarboxylic acid, 2-amino-3-oxo-;*Halothane Impurity 5 (Halothane EP Impurity E) |
CAS号 | 606-59-7 |
分子式 | C14H8N2O6 |
分子量 | 300.22 |
EINECS号 | |
相关类别 | 对照品;Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals |
Mol文件 | 606-59-7.mol |
结构式 |
朱砂精酸 性质
熔点 | >300°C |
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密度 | 1.79 |
储存条件 | 2-8°C |
溶解度 | 二甲基亚砜:≥4mg/mL |
形态 | 粉末 |
颜色 | 红色至深红色 |
稳定性 | 从购买之日起 2 年内保持稳定。 DMSO 或 DMF 溶液可在 -20°C 下保存长达 1 个月。 |
mGluR4
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Cinnabarinic acid (0-100 μM) does not activate mGlu1, mGlu2, mGlu5, mGlu6, mGlu7, and mGlu8 receptors as shown by measurements of [ 3 H]InsP formation. In contrast, cinnabarinic acid acts as a partial agonist of mGlu4 receptors by increasing [ 3 H]InsP formation by approximately 35% at 100 μM, which is 5-fold less efficacious than ACPT-I in activating mGlu4 receptors in HEK293 cells transiently transfected with rat mGlu1, -2, -4, -5, -6, -7, or -8 receptors. Cinnabarinic acid (0-100 μM) reduces cAMP formation in a concentration-dependent manner with an excellent potency and efficacy. At 30 μM, cinnabarinic acid is effective at 30 μM, and substantially inhibits cAMP formation in cultured cerebellar granule cells.
安全信息
WGK Germany | 3 |
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