|
|
| | colletodiol Basic information |
| Product Name: | colletodiol | | Synonyms: | colletodiol;(3E,6R,9E,11R,12R,14R)-11,12-Dihydroxy-6,14-dimethyl-1,7-dioxacyclotetradeca-3,9-diene-2,8-dione;1,7-Dioxacyclotetradeca-3,9-diene-2,8-dione, 11,12-dihydroxy-6,14-dimethyl-, (3E,6R,9E,11R,12R,14R)- | | CAS: | 21142-67-6 | | MF: | C14H20O6 | | MW: | 284.3 | | EINECS: | | | Product Categories: | | | Mol File: | 21142-67-6.mol |  |
| | colletodiol Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble | | form | A solid |
| | colletodiol Usage And Synthesis |
| Description | Colletodiol is a fungal metabolite that has been found in D. grovesii and has immunosuppressant and antiviral activities. It inhibits concanavalin A- or LPS-induced proliferation of isolated mouse splenocytes (IC50s = 12 and 5 μg/ml, respectively). Colletodiol inhibits influenza A viral replication in HeLa-IAV-Luc cells. | | Uses | Colletodiol is a metabolite of Chaetomium funicola and an inhibitor of influenza A virus. Colletodiol can be used to synthesize Grahamimycin A and colletol. | | References | [1] H. FUJIMOTO. Immunosuppressive Components from an Ascomycete, Diplogelasinospora grovesii[J]. ChemInform, 1998, 61 1. DOI: 10.1002/chin.199837278
[2] WENBIN LAI;Xin Y;Shixiong Wang. [Colletodiol inhibits the replication of influenza A virus WSN/H1N1 by reducing the activity of viral RNA polymerase].[J]. Journal of Microbiology, 2013, 53 12: 1334-1339. |
| | colletodiol Preparation Products And Raw materials |
|