| Company Name: |
EMMX Biotechnology LLC
|
| Tel: |
888-539-0666 |
| Email: |
info@emmx.com |
| Products Intro: |
Product Name:BC 11-38
CAS:686770-80-9
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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| Company Name: |
Pharmacodia (Beijing) Co.,Ltd
|
| Tel: |
+86-400-851-9921 |
| Email: |
sales@pharmacodia.com |
| Products Intro: |
Product Name:BC11-38
CAS:686770-80-9
Package:10Mg-100g
|
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| | BC 11-38 Basic information |
| Product Name: | BC 11-38 | | Synonyms: | 3-phenyl-2-(propylthio)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one;6,7-Dihydro-3-phenyl-2-(propylthio)thieno[3,2-d]pyrimidin-4(3H)one;Thieno[3,2-d]pyrimidin-4(3H)-one, 6,7-dihydro-3-phenyl-2-(propylthio)-;cortisol,adrenocortical,Phosphodiesterase (PDE),cAMP,BC 11 38,Inhibitor,production,inhibit,levels,cells,BC11-38,BC 1138 | | CAS: | 686770-80-9 | | MF: | C15H16N2OS2 | | MW: | 304.43 | | EINECS: | | | Product Categories: | | | Mol File: | 686770-80-9.mol |  |
| | BC 11-38 Chemical Properties |
| storage temp. | RT | | solubility | Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 14 mg/ml with warming). | | form | solid | | color | White | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| | BC 11-38 Usage And Synthesis |
| Description | BC-11-38 (686770-80-9) is a? potent and selective inhibitor of phosphodiesterase PDE11 (IC50=0.28 μM).1? IC50s for PDE1-10 are greater than 100 μM. Restores the ability of p54nrb / NONOKD cells to generate cAMP in response to ACTH stimulation and the production of cortisol and DHEA in response to cAMP signaling.2 | | Uses | BC 11-38 is a selective inhibitor of phosphodiesterase 11. Potent PDE-11 inhibitor | | References | 1) Ceyhan et al. (2012), Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen; Chem. Biol., 19 155
2) Lu and Sewer (2015), p54nrb/NONO regulates cyclic AMP-dependent glucocorticoid production by modulating phosphodiesterase mRNA splicing and degradation; Mol. Cell. Biol. 35 1223 |
| | BC 11-38 Preparation Products And Raw materials |
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