DELPAZOLID 基本信息
| 中文名称 | DELPAZOLID |
|---|---|
| 中文同义词 | 化合物DELPAZOLID;(R)-3-(3-氟-4-(1-甲基-5,6-二氢-1,2,4-三嗪-4(1H)-基)苯基)-5-(羟甲基)恶唑烷-2-酮;德帕唑胺 |
| 英文名称 | Delpazolid |
| 英文同义词 | Delpazolid;Delpazolid (LCB01-0371);LCB01-0371;CS-2617;DELPAZOLID; LCB01-0371; LCB 01-0371; LCB-01-0371; LCB010371; LCB 010371; LCB-010371;(5R)-3-[4-(5,6-Dihydro-1-methyl-1,2,4-triazin-4(1H)-yl)-3-fluorophenyl]-5-(hydroxymethyl)-2-oxazolidinone;Delpazolid/(5R)-3-[4-(5,6-Dihydro-1-methyl-1,2,4-triazin-4(1H)-yl)-3-fluorophenyl]-5-(hydroxymethyl)-2-oxazolidinone;2-Oxazolidinone, 3-[4-(5,6-dihydro-1-methyl-1,2,4-triazin-4(1H)-yl)-3-fluorophenyl]-5-(hydroxymethyl)-, (5R)- |
| CAS号 | 1219707-39-7 |
| 分子式 | C14H17FN4O3 |
| 分子量 | 308.31 |
| EINECS号 | |
| 相关类别 | 化学试剂;医用原料 |
| Mol文件 | 1219707-39-7.mol |
| 结构式 |  |
DELPAZOLID 性质
| 沸点 | 481.8±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.44±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO：30.0（最大浓度 mg/mL）；97.3（最大浓度 mM） |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 14.05±0.10(Predicted) |
用途
一种新型的恶唑烷酮类抗生素，能抑制MSSA和MRSA的生长，对它们的MIC90值为2μg/mL。Delpazolid is a new oxazolidinone with cyclic amidrazone. In vitro activity of LCB01-0371 against 624 clinical isolates was evaluated and compared with those of linezolid, vancomycin, and other antibiotics. LCB01-0371 showed good activity against Gram-positive pathogens. In vivo activity of LCB01-0371 against systemic infections in mice was also evaluated. LCB01-0371 was more active than linezolid against these systemic infections. LCB01-0371 showed bacteriostatic activity against Staphylococcus aureus.安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-100180 | Delpazolid | 1 mg | 628元 | |
| 2024/01/25 | HY-100180 | DELPAZOLID Delpazolid | 1219707-39-7 | 5mg | 1000元 |