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| | H-8 DIHYDROCHLORIDE Basic information |
| Product Name: | H-8 DIHYDROCHLORIDE | | Synonyms: | 5-IsoquinolinesulfonaMide,N-[2-(MethylaMino)ethyl]-, hydrochloride (1:2);H-8 DIHYDROCHLORIDE;H-8 HYDROCHLORIDE;H-8;N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE 2HCL;N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE, DI-HCL SALT;N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE DIHYDROCHLORIDE;N-(2-[METHYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE | | CAS: | 113276-94-1 | | MF: | C12H17Cl2N3O2S | | MW: | 338.25 | | EINECS: | | | Product Categories: | | | Mol File: | 113276-94-1.mol |  |
| | H-8 DIHYDROCHLORIDE Chemical Properties |
| Melting point | 221-222℃ (methanol water ) | | storage temp. | 2-8°C | | solubility | ethanol: 25 mg/mL, clear, colorless | | form | Lyophilized | | color | White to Off-White | | CAS DataBase Reference | 113276-94-1(CAS DataBase Reference) |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | HS Code | 29334990 |
| | H-8 DIHYDROCHLORIDE Usage And Synthesis |
| Description | The H series isoquinolinesulfonamide protein kinase (PK) inhibitors are widely used to block signaling pathways to elucidate mechanisms of cellular regulation and signal transduction. H-8, an isoquinolinesulfonamide protein kinase (PK) inhibitor, is a potent inhibitor of PKA and PKG and shows moderate inhibition for PKC and MLCK with Ki values of 1.2, 0.48, 15, and 68 μM, respectively. H-8 can disrupt transcriptional elongation by inhibiting cyclin C/Cdk8 and cyclin H/Cdk7/p36 CTD kinase activity with IC50 values of 47 and 6.2 μM, respectively. | | Chemical Properties | white to off-white crystalline solid | | Uses | Active inhibitor of cyclic-nucleotide-dependent protein kinases. | | Biochem/physiol Actions | cAMP and cGMP-dependent protein kinase inhibitor. |
| | H-8 DIHYDROCHLORIDE Preparation Products And Raw materials |
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