血管紧张素II
中文名称 | 血管紧张素II |
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中文同义词 | ANGIOTENSIN II HUMAN 乙酸盐;血管緊縮素 II;血管紧缩素II;血管紧张素 II 醋酸盐;人血管紧缩素II(-20℃);人血管紧缩素II;血管紧张素II X醋酸盐;(2S,5S,8S,11S,14S,17S)-2-((1H-咪唑-5-基)甲基)-17-氨基-5-((S)-仲丁基)-1-((S)-2-(((S)-1-羧基-2-苯乙基)氨基甲酰)吡咯烷-1-基)-14-(3-胍丙基)-8-(4-羟基苄基)-11-异丙基-1,4,7,10,13,16-六氧代-3,6,9,12,15-五氮杂十九烷-19-酸 X乙酸盐 |
英文名称 | ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE ACETATE SALT |
英文同义词 | ANGIOTENSIN II ACETATE SALT;ANGIOTENSIN II HUMAN ACETATE SALT;ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE ACETATE SALT;HYPERTENSIN II;ANGIOTENSIN II ACETATE HUMAN;ANGIOTENSIN II-FLUORESCEIN SYNTHETIC >81 %;ANGIOTENSIN II, MASS SPEC STANDARD;ANGIOTENSIN II, HUMAN, SYNTHETIC |
CAS号 | 68521-88-0 |
分子式 | C52H75N13O14 |
分子量 | 1106.25 |
EINECS号 | 206-182-3 |
相关类别 | 生物试剂;SignalTransduction;Peptide Receptors;Peptide |
Mol文件 | 68521-88-0.mol |
结构式 |
血管紧张素II 性质
储存条件 | −20°C |
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溶解度 | 在水中的溶解度25 mg/mL,澄清,无色 |
形态 | 粉末 |
颜色 | 橙色 |
Most of the known actions of Angiotensin II (Ang II) are mediated by AT 1 receptors, the AT 2 receptor contributes to the regulation of blood pressure and renal function. Angiotensin II raises blood pressure (BP) by a number of actions, the most important ones being vasoconstriction, sympathetic nervous stimulation, increased aldosterone biosynthesis and renal actions. Other Angiotensin II actions include induction of growth, cell migration, and mitosis of vascular smooth muscle cells, increased synthesis of collagen type I and III in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. These actions are mediated by type 1 Ang II receptors (AT 1 ). At the cellular level, responsiveness to Angiotensin II is conferred by the expression of the two classes of angiotensin receptors (AT 1 and AT 2 ). The effects of Angiotensin II to increase blood pressure are mediated by AT1 receptors.
To distinguish the AT 1 receptor population that is critical for the pathogenesis of hypertension, osmotic minipumps are implanted s.c. into each animal to infuse Angiotensin II (1,000 ng/kg/min) continuously for 4 weeks. Angiotensin II causes hypertension by activating AT 1 receptors in the kidney promoting sodium reabsorption.
安全信息
WGK Germany | 3 |
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F | 3-10 |
提供商 | 语言 |
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英文
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