血管紧张素
| 中文名称 | 血管紧张素 |
|---|---|
| 中文同义词 | 血管紧张素;醋酸血管紧张素 II ANGIOTENSINII ACETATE;[VAL5]-血管紧张素 II 乙酸盐 水合物;ANGIOTENSIN受体激动剂(ANGIOTENSIN II 5-VALINE);血管紧张素 Ⅱ 5-缬氨酸, >99%;[VAL5]-血管紧张素 II;血管紧张素 Ⅱ 5-缬氨酸;血管紧张素 Ⅱ 5-缬氨酸 |
| 英文名称 | Angiotensin acetate |
| 英文同义词 | [VAL5]-ANGIOTENSIN II;[VAL5] ANGIOTENSIN II HUMAN;ASP-ARG-VAL-TYR-VAL-HIS-PRO-PHE;DRVYVHPF;L-ASP-ARG-VAL-TYR-VAL-HIS-PRO-PHE;H-ASP-ARG-VAL-TYR-VAL-HIS-PRO-PHE-OH;[val5]-angiotensin ii acetate hydrate;Angiotensin acetate |
| CAS号 | 58-49-1 |
| 分子式 | C49H69N13O12 |
| 分子量 | 1032.17 |
| EINECS号 | |
| 相关类别 | 多肽中间体;医药原料;多肽;医药原料药;多肽-客户肽;细胞生物学试剂;对照品-中药对照品;药物多肽;肽类 |
| Mol文件 | 58-49-1.mol |
| 结构式 |  |
血管紧张素 性质
| 储存条件 | -20°C |
|---|---|
| 形态 | 粉末 |
| 密度 | 1.45±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | 3.56±0.10(Predicted) |
| 水溶解性 | Water : ≥ 257.5 mg/mL (249.48 mM) |
| 序列 | H-Asp-Arg-Val-Tyr-Val-His-Pro-Phe-OH |
| InChIKey | JVCJXRGXGITABA-IAQGTVMASA-N |
| CAS 数据库 | 58-49-1 |
Angiotensin receptor.
By day 12, systolic blood pressure (SBP) increases significantly in Angiotensin II 5-valine infused rats (197±7 mm Hg). As shown, the development of hypertension in ANG II infused rats is prevented by losartan treatment. Blood and kidney samples are harvested, subjected to HPLC to separate Angiotensin II 5-valine (exogenous) from Ile5-ANG II (endogenous) and the fractions are measured by radioimmunoassay. In the Angiotensin II 5-valine infused rats treated with losartan, total plasma ANG II levels are elevated to a greater extent than in rats not treated with losartan (289±20 v 119±14 fmol/mL). However, losartan markedly decrease by 88% the enhancement of intrarenal Val5-ANG II content that occurred in the rats infused with Val5-ANG II alone.
纯度(HPLC) ≥98.0%
醋酸根含量5.0%～12.0%
水分含量≤8.0%
肽含量≥80.0%
安全信息
| WGK Germany | 3 |
|---|