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BOC Sciences
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Product Name:SW203668 trifluoroacetate salt
CAS:2117405-48-6
Purity:98% Package:1G;10G;100G Remarks:SW203668 is an irreversible inhibitor of stearoyl-CoA desaturase (IC50 = 54 nM). It is selectively cytotoxic to H2122, H460, HCC44, and HCC95 cell lines.
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Shanghai Hongye Biotechnology Co. Ltd
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Product Name:SW203668 (trifluoroacetate salt)
CAS:2117405-48-6
Purity:>98% Package:1mg;10mg;50mg;100mg;
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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Product Name:SW203668 trifluoroacetate salt
CAS:2117405-48-6
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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Shanghai Yifei Biotechnology Co. , Ltd.
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021-65675885 18964387627 |
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| Products Intro: |
Product Name:SW203668 (trifluoroacetate salt)
CAS:2117405-48-6
Purity:98% Package:1mg;5mg;10mg
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SW203668 (trifluoroacetate salt) manufacturers
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| | SW203668 (trifluoroacetate salt) Basic information |
| Product Name: | SW203668 (trifluoroacetate salt) | | Synonyms: | SW203668 (trifluoroacetate salt);SW203668 (trifluoroacetate salt),SW-203668 (trifluoroacetate salt);4-(aminophenylmethyl)-N-(6-methoxy-2-benzothiazolyl)-benzamide,trifluoroacetatesalt | | CAS: | 2117405-48-6 | | MF: | C24H20F3N3O4S | | MW: | 503.5 | | EINECS: | | | Product Categories: | | | Mol File: | 2117405-48-6.mol |  |
| | SW203668 (trifluoroacetate salt) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 20 mg/mL; DMSO: 20 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/mL | | form | A crystalline solid |
| | SW203668 (trifluoroacetate salt) Usage And Synthesis |
| Description | SW203668 is an irreversible inhibitor of stearoyl-CoA desaturase (IC50 = 54 nM). It is selectively cytotoxic to H2122, H460, HCC44, and HCC95 cell lines that express cytochrome P450 (CYP) isoform CYP4F11 over eight other cancer cell lines that lack CYP4F11 in vitro (IC50s = 22-116 and >10,000 nM, respectively) and ectopic expression of CYP4F11 in SW203668-insensitive H1155 cells results in sensitization to SW203668. In vivo, SW203668 reduces tumor growth rate without reducing sebocyte production in the H2122 wild-type and nonobese diabetic severe combined immunodeficiency (NOD-SCID) mouse xenograft models when administered at doses of 20 and 6 mg/kg, respectively. | | Uses | SW203668 TFA is a benzothiazole compound, shows anti-tumor activity against lung cancer cell lines (IC50=0.022-0.116 μM) | | References | [1] Theodoropoulos PC, et al. Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase. Nat Chem Biol. 2016 Apr;12(4):218-25. DOI:10.1038/nchembio.2016 |
| | SW203668 (trifluoroacetate salt) Preparation Products And Raw materials |
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