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SULFOTEP Basic information
Product Name:SULFOTEP
Synonyms:O,O,O',O'-TETRAETHYLDITHIOPYRO PHOSPHATE;THIOTEP;THIOTEPP(R);Thiodiphosphoric acid tetraethyl ester;TETRAETHYLDITHIO PYROPHOSPHATE;SULFOTEP;plantfume103smokegenerator;Pyrophosphoric acid, tetraethyldithio-
Product Categories:Agro-products;Inhibitors;INSECTICIDE;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
Mol File:3689-24-5.mol
SULFOTEP Structure
SULFOTEP Chemical Properties
Melting point <25℃
Boiling point bp2 136-139°
density 1.2175 g/cm3 (20℃)
vapor pressure 1.7 x 10-4 at 20 °C (Windholz et al., 1983)
refractive index 1.5000 (589.3 nm 20℃)
Fp -18 °C
storage temp. APPROX 4°C
solubility Miscible with methyl chloride and most organic solvents (Worthing and Hance, 1991)
form Liquid
color Clear colorless
Water Solubility 30 mg/L at 20 °C (Worthing and Hance, 1991)
Merck 13,9056
BRN 1714019
Henry's Law Constant2.88 at 20 °C (approximate - calculated from water solubility and vapor pressure)
Exposure limitsNIOSH REL: TWA 0.2 mg/m3, IDLH 10 mg/m3; ACGIH TLV: TWA 0.2 mg/m3.
EPA Substance Registry SystemSulfotep (3689-24-5)
Safety Information
Hazard Codes T+,N,Xn,F
Risk Statements 27/28-50/53-67-65-38-11
Safety Statements 23-28-36/37-45-60-61-62
WGK Germany 3
RTECS XN4375000
HazardClass 6.1(a)
PackingGroup II
HS Code 29209090
Hazardous Substances Data3689-24-5(Hazardous Substances Data)
ToxicityLD50 s.c. in mice: 8 mg/kg (Holmstedt)
MSDS Information
SULFOTEP Usage And Synthesis
Chemical PropertiesYellowliquid. Slightly soluble in water; soluble in most organic solvents.
Chemical PropertiesSulfotep is a yellow mobile liquid. Garliclike odor.
UsesAn organophosphate pesticide that is an inhibitor of acetylcholinesterase (AChE).
UsesInsecticide; miticide.
UsesSulfotep is used to control aphids, thrips, mites and whiteflies in glasshouses by fumigation. It also used to control sciarid and phorid flies in mushrooms.
General DescriptionTetraethyl dithiopyrophosphate and compressed gas mixture is a liquid charged with a gas. Tetraethyl dithiopyrophosphate is a yellow liquid. Its vapor is heavier than air. SULFOTEP is lethal by skin absorption and inhalation. Prolonged exposure of the containers to fire or heat may result in their violent rupturing and rocketing.
Reactivity ProfileOrganothiophosphates, such as TETRAETHYL DITHIOPYROPHOSPHATE, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides. SULFOTEP is incompatible with the following: Strong oxidizers, iron [Note: Corrosive to iron.] .
HazardToxic by ingestion, inhalation, and skin absorption; cholinesterase inhibitor; use may be restricted. Questionable carcinogen.
Safety ProfilePoison by ingestion, skin contact, inhalation, intramuscular, intraperitoneal, subcutaneous, and intravenous routes. A cholinesterase inhbitor type of insecticide. When heated to decomposition it emits toxic fumes of POx and SOx. See also PARATHION.
Potential ExposureSulfotep is used in greenhouse fumigant formulations for control of aphids, spider mites; thrips, whiteflies, etc.
Environmental FateSoil. Cleavage of the molecule yields diethyl phosphate, monoethyl phosphate and phosphoric acid (Hartley and Kidd, 1987).
Chemical/Physical. Emits toxic oxides of sulfur and phosphorus oxides when heated to decomposition (Lewis, 1990).
Metabolic pathwaySulfotep and related compounds may be formed photochemically from a number of phosphorodithioate and phosphorothioate insecticides including azinphos-methyl, chlorpyrifos, malathion, methidathion and phosalone (Abdelbagi and Gaston, 1998). Since sulfotep has a rather high mammalian toxicity, this may be of some toxicological sigruficance. Sulfotep is transformed in the environment via oxidative desulfuration to the highly active anti-cholinesterase compounds monosulfotep and tetraethyl pyrophosphate. It is deactivated by hydrolysis to O,O-diethyl phosphorothioate and diethyl phosphate.
ShippingUN1704 (Sulfotep) Tetraethyl dithiopyrophosphate, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
DegradationSulfotep is relatively slowly hydrolysed with DT50 values of 10.7,8.2 and 9.1 days at pH values 4,7 and 9 respectively (PM).
Toxicity evaluationSulfotep is formulated as fumigant. The acute oral LD50 for rats is about 10 mg/kg. Inhalation LC50 (4 h) for rats is about 0.05 mg/L air. NOEL (2 yr) for rats is 10mg/kg diet (0.5mg/kg/d). ADI is 1 μg/kg b.w. Sulfotep is activated by oxidative desulfuration to tetraethyl monothiopyrophosphate and pyrophosphate in the environment. Sulfotep administered to rats is quickly eliminated. The major elimination product is diethyl hydrogen phosphorothioate.
IncompatibilitiesIncompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine,bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Hydrolyzes very slowly in aqueous solution. Attacks some forms of plastic, rubber and coating. Corrosive to iron.
Waste DisposalConsult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office. Incineration with added flammable solvent in furnace equipped with afterburner and alkaline scrubber.
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