2-CHLOROPYRIDINE-5-ACETIC ACID ETHYL ESTER manufacturers
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| | 2-CHLOROPYRIDINE-5-ACETIC ACID ETHYL ESTER Basic information |
| Product Name: | 2-CHLOROPYRIDINE-5-ACETIC ACID ETHYL ESTER | | Synonyms: | Ethyl 2-(6-chloropyridin-3-yl)acetate;ETHYL (6-CHLOROPYRIDIN-3-YL)-ACETATE;6-Chloro-3-pyridineacetic acid ethyl ester;2-CHLOROPYRIDINE-5-ACETIC ACID ETHYL ESTER;3-Pyridineacetic acid, 6-chloro-, ethyl ester;Ethyl 6-Chloropyridine-3-acetate;2-CHLOROPYRIDINE-5-ACETIC ACID ETHYL ESTER ISO 9001：2015 REACH;Ethyl 2-Chloropyridine-5-acetate | | CAS: | 197376-47-9 | | MF: | C9H10ClNO2 | | MW: | 199.63 | | EINECS: | | | Product Categories: | pyridine series;Pyridine;Pyridines | | Mol File: | 197376-47-9.mol |  |
| | 2-CHLOROPYRIDINE-5-ACETIC ACID ETHYL ESTER Chemical Properties |
| Boiling point | 285.8±25.0 °C(Predicted) | | density | 1.217±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | -0.34±0.10(Predicted) | | Appearance | Colorless to light yellow Liquid | | InChI | InChI=1S/C9H10ClNO2/c1-2-13-9(12)5-7-3-4-8(10)11-6-7/h3-4,6H,2,5H2,1H3 | | InChIKey | HNMKCAOYIPYXRD-UHFFFAOYSA-N | | SMILES | C1=NC(Cl)=CC=C1CC(OCC)=O |
| | 2-CHLOROPYRIDINE-5-ACETIC ACID ETHYL ESTER Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of ethyl 2-(6-chloropyridin-3-yl)acetate from ethanol and 2-chloropyridine-5-acetic acid was as follows: to an ethanolic solution of 6-chloro-3-pyridineacetic acid (1 g, 5.83 mmol) was slowly added concentrated sulfuric acid (1.6 mL). The reaction mixture was heated to reflux and kept for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature and concentrated in a rotary evaporator to remove most of the ethanol. The concentrated residue was dissolved in ethyl acetate and subsequently washed with saturated sodium bicarbonate solution to neutralize the residual acid. The organic phase was dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the crude product. Finally, the crude product was purified by silica gel column chromatography to afford ethyl 2-(6-chloropyridin-3-yl)acetate (1.1 g, 95% yield). | | References | [1] Patent: WO2013/13817, 2013, A1. Location in patent: Page/Page column 99
[2] Patent: WO2013/13815, 2013, A1. Location in patent: Page/Page column 147
[3] Patent: US2013/29961, 2013, A1. Location in patent: Paragraph 0664
[4] Patent: US2013/29962, 2013, A1. Location in patent: Paragraph 0815
[5] Chemical Communications, 2015, vol. 51, # 84, p. 15446 - 15449 |
| | 2-CHLOROPYRIDINE-5-ACETIC ACID ETHYL ESTER Preparation Products And Raw materials |
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