番茄碱
| 中文名称 | 番茄碱 |
|---|---|
| 中文同义词 | 番茄碱, 来源于番茄;番茄碱?, >98%;番茄碱对照品;番茄碱标准品 |
| 英文名称 | TOMATIDINE |
| 英文同义词 | SPIRPSOLAN-3-OL-(3beta,5alpha,22beta,25delta);22S,25S,5ALPHA-TOMATANIN-3BETA-OL;SPIROSOLAN-3-OL-(3BETA,5ALPHA,22BETA,25ALPHA);SPIRPSOLAN-3-OL-(3BETA,5ALPHA,22BETA,25ALPHA);TOMATIDINE;5alpha-Tomatidan-3beta-ol;Spirosolan-3-ol;Spirosolan-3-ol, (3beta,5alpha,22beta,25S)- |
| CAS号 | 77-59-8 |
| 分子式 | C27H45NO2 |
| 分子量 | 415.65 |
| EINECS号 | 201-040-3 |
| 相关类别 | 医药中间体;植物提取物;标准品;对照品;中药对照品;生化试剂-其他化学试剂;分析试剂标准品;对照品-中药对照品;Alkaloids;标准品 -中药标准品 |
| Mol文件 | 77-59-8.mol |
| 结构式 |  |
番茄碱 性质
| 熔点 | 210.5℃ |
|---|---|
| 比旋光度 | D25 +8° (chloroform) |
| 沸点 | 534.2°C (rough estimate) |
| 密度 | 1.0048 (rough estimate) |
| 折射率 | 1.6840 (estimate) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO：2.86 mg/mL (6.88 mM)；水：< 0.1 mg/mL（不溶） |
| 酸度系数(pKa) | 15.14±0.70(Predicted) |
| LogP | 6.150 (est) |
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p65
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JNK
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Tomatidine decreases inducible NO synthase and COX-2 expression through suppression of I-κBα phosphorylation, NF-κB nuclear translocation and JNK activation, which in turn inhibits c-jun phosphorylation and Oct-2 expression. Tomatidine, solasodine and diosgenin (40 μM) show 66%, 22% and 41% inhibition of nitrite production, respectively. The iNOS protein is barely detectable in unstimulated cells but markedly increases after LPS treatment, and Tomatidine causes dose-dependent inhibition of LPS-induced iNOS expression. p65 is the major component of NF-κB in LPS-stimulated macrophages, the effect of Tomatidine on p65 DNA-binding activity is determined. In the presence of Tomatidine at 10-40 μM, the binding activity of NF-κB is suppressed in a dose-dependent manner. Tomatidine inhibits the phosphorylation of I-κB, blocks the I-κB production, and furthermore suppresses p65 NF-κB translocation to the nucleus and modulated binding activity.