7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE
| 中文名称 | 7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE |
|---|---|
| 中文同义词 | 化合物 T16766;化合物RO 08-2750 |
| 英文名称 | RO 08-2750 |
| 英文同义词 | 2,3,4,10-Tetrahydro-7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carboxaldehyde;RO 08-2750;7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE;Benzo[g]pteridine-8-carboxaldehyde, 2,3,4,10-tetrahydro-7,10-dimethyl-2,4-dioxo-;growth,MSI,Ro 082750,p75NTR,TRKA,RNA-binding,Nerve,NGF,Inhibitor,leukemia,Apoptosis,AML,Ro 08-2750,inhibit,Ro 08 2750,factor,MUSASHI;7,10-dimethyl-2,4-dioxo-2,3,4,10-tetrahydrobenzo[g]pteridine-8-carbaldehyde |
| CAS号 | 37854-59-4 |
| 分子式 | C13H10N4O3 |
| 分子量 | 270.24 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 37854-59-4.mol |
| 结构式 | ![7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE 结构式](CAS/GIF/37854-59-4.gif) |
7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | DMSO 中≤2.7mg/ml |
| 形态 | 固体 |
| 颜色 | 橙色 |
Ro 08-2750 是一种非肽、可逆的 NGF 抑制剂，能直接结合 NGF，IC50 值为 ~ 1 µM。Ro 08-2750 能抑制 NGF 结合 p75NTR 的优于 TRKA。Ro 08-2750 是选择性的 MSI RNA 结合抑制剂，其作用的 IC50 值为 2.7 μM。
IC50: ~1 µM (NGF), 2.7 μM (MSI RNA-binding)
Ro 08-2750 binds to the NGF dimer thereby probably inducing a change in its conformation such that NGF cannot bind to p75
NTR
anymore.
Ro 08-2750 (10 nM) completely rescues cells from undergoing NGF-induced SK-N-MC 103 cells death.
Ro 08-2750 (5-10 μM; 8 hours) increases differentiation and apoptosis in myeloid leukemia cells.
Ro 08-2750 inhibits survival of human AML lines and patient cells.
Ro 08-2750 inhibits MSI2 RNA-binding and alters MSI2 gene signature.
Apoptosis Analysis
| Cell Line: | MLL-AF9 + BM cells |
| Concentration: | 5 μM, 10 μM |
| Incubation Time: | 8 hours |
| Result: | Increased apoptosis. |
Ro 08-2750 (13.75 mg/kg; i.p.) inhibits leukemogenesis in a myeloid leukemia model in vivo.
| Animal Model: | C57BL/6 wild type mice (10-12-weeks-old), MLL-AF9 murine leukemia model |
| Dosage: | 13.75 mg/kg |
| Administration: | Intraperitoneal injection, at days 1, 4, 7, 10, and 13 (one day on, two days off drug) |
| Result: | Inhibited c-MYC levels and reduced disease burden. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-108466 | 7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE Ro 08-2750 | 37854-59-4 | 1mg | 288元 |
| 2024/01/25 | HY-108466 | 7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE Ro 08-2750 | 37854-59-4 | 5mg | 720元 |