Forodesine manufacturers
- Forodesine
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- $15.00 / 1KG
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2021-07-13
- CAS:209799-67-7
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- Forodesine
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- $15.00 / 1KG
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2021-07-09
- CAS:209799-67-7
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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| | Forodesine Basic information |
| Product Name: | Forodesine | | Synonyms: | 4H-Pyrrolo3,2-dpyrimidin-4-one, 7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-;Forodesine;7-[(2S,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one;Fodosine;Immucillin-H;(1S)-1-(9-deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-iMino-D-ribitol, iMMucillin H;FORODESINE FODOSINE;4H-Pyrrolo[3,2-d]pyriMidin-4-one,7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxyMethyl)-2-pyrrolidinyl]-3,5-dihydro- | | CAS: | 209799-67-7 | | MF: | C11H14N4O4 | | MW: | 266.25 | | EINECS: | | | Product Categories: | | | Mol File: | 209799-67-7.mol |  |
| | Forodesine Chemical Properties |
| Boiling point | 613.5±65.0 °C(Predicted) | | density | 2.01 | | storage temp. | Hygroscopic, Refrigerator, under inert atmosphere | | solubility | PBS (pH 7.2): 5 mg/ml | | form | A crystalline solid | | pka | 13.88±0.70(Predicted) | | color | Light brown to gray |
| | Forodesine Usage And Synthesis |
| Description | Forodesine is a purine nucleoside analog and purine nucleoside phosphorylase (PNP) inhibitor (IC50s = 1.19, 0.48, 1.24, 0.66, and 1.57 nM for human, mouse, rat, monkey, and dog PNP, respectively). It inhibits phytohemagglutinin A-, mixed lymphocyte reaction-, or IL-2-induced proliferation of isolated human peripheral blood lymphocytes (PBLs; IC50s = <0.1-0.38 μM) in the presence, but not absence, of 2’-deoxyguanosine (dGuo). Forodesine inhibits proliferation of CEM-SS T cell acute lymphoblastic leukemia (T-ALL) cells. In vivo, forodesine (10 mg/kg) prolongs survival in the hu-PBL-SCID mouse model of xenogeneic graft versus host disease (GVHD). | | Uses | Fodosine is a 23-pM inhibitor of bovine purine nucleoside phosphorylase (PNP) specifically designed as a transition state mimic. | | Uses | Treatment of T-Cell malignancies such as acute lymphoblastic leukemia (ALL) and cutaneous T-cell lymphoma (CTCL) Fodosine. | | Definition | ChEBI: Immucillin H is a pyrrolopyrimidine and a dihydroxypyrrolidine. |
| | Forodesine Preparation Products And Raw materials |
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