N-delta-chloroacetyl-L-ornithine

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N-delta-chloroacetyl-L-ornithine Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
N-delta-chloroacetyl-L-ornithine Basic information
Product Name:N-delta-chloroacetyl-L-ornithine
Synonyms:N-delta-chloroacetyl-L-ornithine;L-Ornithine, N5-(2-chloroacetyl)-;NCAO
CAS:20584-81-0
MF:C7H13ClN2O3
MW:208.64
EINECS:
Product Categories:
Mol File:20584-81-0.mol
N-delta-chloroacetyl-L-ornithine Structure
N-delta-chloroacetyl-L-ornithine Chemical Properties
Boiling point 469.0±45.0 °C(Predicted)
density 1.303±0.06 g/cm3(Predicted)
pka2.49±0.24(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
N-delta-chloroacetyl-L-ornithine Usage And Synthesis
UsesN-ω-chloroacetyl-L-ornithine (NCAO) is a potent reversible competitive ornithine decarboxylase (ODC) inhibitor that exerts cytotoxic and antiproliferative effects on tumor cell lines with EC50 values ranging from 1 to 50.6 μM. NCAO induces tumor cell Apoptosis and inhibits tumor cell migration in vitro. NCAO also exhibits a potent antitumor activity against both solid and ascitic tumors in a mouse model using the myeloma (Ag8) cell line. NCAO is promising for research of antitumor agents[1].
References[1] Vargas-Ramírez AL, et al. N-ω-chloroacetyl-L-ornithine has in-vitro activity against cancer cell lines and in-vivo activity against ascitic and solid tumors. Anticancer Drugs. 2016 Jul;27(6):508-18. DOI:10.1097/CAD.0000000000000353
N-delta-chloroacetyl-L-ornithine Preparation Products And Raw materials
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