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Doramectin

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Company Name: SHANDONG ZHI SHANG CHEMICAL CO.LTD
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Products Intro: Product Name:Doramectin
CAS:117704-25-3
Purity:0.99 Package:25kg/drum
Company Name: Casorganics US Corp
Tel: +17326109938
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Products Intro: Product Name:Doramectin
CAS:117704-25-3
Purity:>99% Package:500G;USD|1KG;USD|10KG;USD|25KG;USD
Company Name: ENBRIDGE PHARMTECH CO., LTD.
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Products Intro: Product Name:Doramectin
CAS:117704-25-3
Package:25KG
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: info@dakenchem.com
Products Intro: Product Name:Doramectin
CAS:117704-25-3
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: Product Name:117704-25-3
CAS:117704-25-3
Purity:0.99 Package:25KG,5KG;1KG;500G

Lastest Price from Doramectin manufacturers

  • Doramectin
  • US $1230.00 / KG
  • 2020-06-04
  • CAS:117704-25-3
  • Min. Order: 1KG
  • Purity: 95% USP
  • Supply Ability: 2000KG
  • Doramectin
  • US $0.00-0.00 / KG
  • 2020-04-29
  • CAS:117704-25-3
  • Min. Order: 1KG
  • Purity: 99.0%+
  • Supply Ability: 800 tons
  • Doramectin
  • US $1.00 / Kg/Drum
  • 2019-10-30
  • CAS:117704-25-3
  • Min. Order: 25Kg/Drum
  • Purity: 99%
  • Supply Ability: 1ton
Doramectin Basic information
Pig antiparasitic Pharmacological effects Precautions
Product Name:Doramectin
Synonyms:25-CYCLOHEXYL-5-O-DEMETHYL-25-DE(1-METHYLPROPYL)AVERMECTIN; 25-Cclohexyl-avermectin B1;25-Cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)avermectin A1A;Dectoma;UK-67994;Avermectin A1a, 25-cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)-;doramectine;DONGGUAI.P.E
CAS:117704-25-3
MF:C50H74O14
MW:899.11
EINECS:601-490-4
Product Categories:API;Inhibitors;Pharmaceuticals;IMIPEM;raw material;Antiparasitic;Intermediates & Fine Chemicals
Mol File:117704-25-3.mol
Doramectin Structure
Doramectin Chemical Properties
Melting point 116-1190C
Boiling point 967.4±65.0 °C(Predicted)
density 1.25±0.1 g/cm3(Predicted)
storage temp. 0-6°C
solubility methanol: soluble
pka12.42±0.70(Predicted)
form solid
color white
InChIKeyQLFZZSKTJWDQOS-YDBLARSUSA-N
Safety Information
Hazard Codes T,N,Xi
Risk Statements 25-50/53-36/37/38
Safety Statements 33-45-60-61-36/37-26
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
HS Code 29419090
Hazardous Substances Data117704-25-3(Hazardous Substances Data)
MSDS Information
ProviderLanguage
Doramectin English
Doramectin Usage And Synthesis
Pig antiparasiticDoramectin is a new generation of antiparasitic , compared with other commercially available ivermectin products, anti-parasite range of Doramectin is broader, with better effect, and Doramectin can prevent parasite reinfection for a longer valid time, It is the world's best, the most potential anti-parasitic drugs for development veterinary .
Doramectin as a pesticide can kill all the the internal and external parasites , and is also valid to nematodes, arthropods. At present, Chinese pig industry commonly used insecticide drugs include: parasite drugs: albendazole, levamisole, trichlorfon, Vietnam, hygromycin, ivermectin, avermectin. External parasite drugs: trichlorfon, amitraz, diazinon, permethrin drugs, avermectin, ivermectin.
Doramectin has a good effect on pig gastrointestinal nematodes , it is reported that pig is injected 0.3 mg/kg by intramuscular, dosing artificial and natural infection cases after 7 days , 14 days, 21 days, weight gains is significantly higher (swine P <0.0001); compared with the control group, percentage of getting rid of worms is 100%, and there are no side effects.
In Pig scabies mite treatment, from piglets to sows ,Doramectin has good results .After artificial infection scabies mites, according to the body weight ,administrated 0.3 mg/kg intramuscularly, four weeks after the test, the result of inflammation of the skin injury in pigs and worms Elimination of infected body, is very significant (P <0.05). Treatment for pregnant sows kidney worm, press the 0.3 mg/kg dose neck single injection, the 56 day and 57 day of testing, the detection rate of Urine eggs is 0, the percentage of getting rid of them is 100%, while the control group per milliliter of urine displays 3762 eggs. For lung worms, lice and other pigs parasites,it has the same effect.
According to more than l ng/g tissue concentration of the drug having anti-parasitic activity, the drug can be used to assess the validity.
Duration time of Ivermectin is greater than 1 ng/g concentration :18 days for the skin, the lungs 18 days, 18 days for gastrointestinal mucosa, gastric mucosa wrinkled 18 days.
Duration time of Doramectin is greater than 1 ng/g concentration: 26 days for the skin, the lungs 38 days, 38 days for gastrointestinal mucosa, gastric mucosa wrinkled 38 days.
Thus,duration time of more than 1 ng/g doramectin in the gastrointestinal mucosa, lung tissue is 38 days, 20 days more than ivermectin.
So the effect of doramectin to drive and to kill the parasites is stronger than ivermectin, and it can be effective to prevent the parasite reinfection .
The above information is edited by the Chemicalbook of Tian Ye.
Pharmacological effects[Chemical properties] brown powder , very low solubility in water.
Doramectin is used for the treatment of livestock diseases such as nematodes and mites ectoparasitosis,it is fermented by recombinant avermitilis (Streptomyces avermitilis) new strain, and the main difference from ivermectin is that C25 is substituted by cyclohexyl. It is a new, broad-spectrum antiparasitic drug,and is efficient for gastrointestinal nematodes, lung nematodes, Euglena, lice, ticks, mites and wound maggots , also has a good effect on internal and external parasites especially certain nematodes (round worms) and arthropods , but invalid to tapeworms, flukes and protozoa . Its mechanism of action is to increase the release of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) of the worm, thereby blocking the transmission of nerve signals, so that muscle cells lose their ability to contract, resulting in death of the parasites. the neurotransmitter of Peripheral nerves of mammals is acetylcholine,and will not be affected by Doramectin, doramectin cannot go through the blood-brain barrier easily , minimal damage to the central nervous system,safe to cattle. The main feature is that the plasma concentration and half-life are higher or twice than Ivermectin. The United States has approved to use as cattle, pigs and dedicated injection and cattle dedicated pour.
Precautions1, doramectin is unstable and decomposes rapidly in the sunlight to be inactivated, its remnants of drugs are toxic to fish and aquatic organisms, so pay attention to water protection.
2, pour-on: bovine application, not rain within 6 hours.
3, use with caution in dogs.
4, the goods will be placed out of reach of children, the operator should not eat or smoking, wash hands after handling.
5, withdrawal period, 35 days of cattle, pigs 24 days.
DescriptionDoramectin is a novel avermectin with a cyclohexyl substituent on the previously inaccessible C-25 position of the molecule; the substitution was facilitated by mutational biosynthesis. The discovery of doramectin involved feeding carboxylic acids or their precursors to a fermentation of Streptomyces avermitilis that lacked branched-chain 2-oxo acid dehydrogenase activity, and then screening the resultant fermentation products for anthelmintic and ectoparasiticidal activity (89).
Two dosage forms of doramectin have been developed for use as an endectocide on cattle, an injectable formulation for subcutaneous administration and a pouron formulation. An injectable formulation is also approved for use on pigs.
Chemical PropertiesWhite Solid
Usesantibacterial
UsesDoramectin is a biosynthetic avermectin derived from a mutant strain of Streptomyces avermitilis, supplemented with a cyclohexylcaboxylic acid starting unit. Doramectin was developed as an anthelmintic for internal parasite control. The presence of the cyclohexyl group replacing the sec-butyl moiety affords greater hydrophobicity and longer biological half-life compared to avermectin. Like the other milbemycin/avermectins, it selectively binds to parasite glutamate-gated chloride ion channels and disrupts neurotransmission leading to paralysis and death of the parasite.
UsesA mutational biosynthetic antiparasitic antibiotic.
UsesMutational biosynthetic antiparasitic antibiotic structurally related to the avermectins
Veterinary Drugs and TreatmentsDoramectin injection is indicated for the treatment and control of the following endo- and ectoparasites in cattle: roundworms (adults and some fourth stage larvae)—Ostertagia ostertagi (including inhibited larvae), O. lyrata, Haemonchus placei, Trichostrongylus axei, T. colubriformis, T. longispicularis, Cooperia oncophora, C. pectinata, C. punctata, C. surnabada (syn. mcmasteri), Bunostomum phlebotomum, Strongyloides papillosus, Oesophagostomum radiatum, Trichuris spp.; lungworms (adults and fourth stage larvae)—Dictyocaulus viviparus; eyeworms (adults)—Thelazia spp.; grubs (parasitic stages)—Hypoderma bovis, H. lineatum; lice—Haematopinus eurysternus, Linognathus vituli, Solenopotes capillatus; and mange mites—Psoroptes bovis, Sarcoptes scabiei.
In swine the injection is labeled for the treatment and control gastrointestinal roundworms (adults and 4th stage Ascaris suum, adults and 4th stage Oesophagostomum dentatum, Oesophagostomum quadrispinolatum adults, Strongyloides ransomi adults, and Hydrostrongylus rubidus adults), lungworms (Stephanurus dentatus adults), mange mites (adults and immature stages Sarcoptes scabeii var. suis), and sucking lice (adults and immature stages Haematopinus suis)
The manufacturer states the doramectin protects cattle against infection or reinfection with Ostertagia ostertagi for up to 21 days. Doramectin topical (pour-on) is approved for use in cattle and has a similar spectrum of action against a variety of endo- and ectoparasites, including biting lice.
Injectable doramectin has been used for treating a variety of nematode and arthropod parasites in companion animals, including generalized demodicosis in dogs and cats and spirocercosis in dogs.
Doramectin Preparation Products And Raw materials
Tag:Doramectin(117704-25-3) Related Product Information
Tangeretin Nitazoxanide Indigo (E)-4-ETHOXY-NONA-1,5-DIENE HEPTA-4,6-DIENOIC ACID trans-3-Hydroxyhex-4-enoic acid, min. 95 % (1H-NMR) CARVEOL Doramectin LAVANDULOL Avermectin B1a (+)-Dipentene (E)-HEPTA-4,6-DIENOIC ACID ETHYL ESTER Avermectin B1b 2-PROPYL-3-PENTENOIC ACID METHYL HEPTA-4,6-DIENOATE ETHYL 2-METHYL-3-PENTENOATE (+/-)-LAVANDULOL