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LOMIFYLLINE

LOMIFYLLINE Suppliers list
Company Name: career henan chemical co
Tel: 0086-371-86658258
Email: factory@coreychem.com
Products Intro: Product Name: LOMIFYLLINE
CAS:10226-54-7
Purity:99% Package:1g;1USD
Company Name: Dideu Industries Group Limited
Tel: 029-88380327; 17691182729
Email: Service@dideu.com
Products Intro: Product Name:LOMIFYLLINE USP/EP/BP
CAS:10226-54-7
Purity:99.9% Package:1g;1.1USD Remarks:FDA GMP CEP Approved Manufacturer
Company Name: J & K SCIENTIFIC LTD.  
Tel: 010-82848833- ;010-82848833-
Email: jkinfo@jkchemical.com;market6@jkchemical.com
Products Intro: Product Name:LoMifylline
CAS:10226-54-7
Package:500Mg,50Mg
Company Name: LGM Pharma  
Tel: 1-(800)-881-8210
Email: inquiries@lgmpharma.com
Products Intro: Product Name:LoMifylline
CAS:10226-54-7
Purity:Typically NLT 98%
Company Name: Chemsky (shanghai) International Co.,Ltd  
Tel: 021-50135380
Email: shchemsky@sina.com
Products Intro: Product Name:LoMifylline;3,7-Dihydro-1,3-diMethyl-7-(5-oxohexyl)-1H-purine-2,6-dione; 7-(5-Oxohexyl)theophylline; 1,3-DiMethyl-7-(5-oxohexyl)xanthine; 7-(5-Oxohexyl)-1,3-diMethylxanthine; Cervilane
CAS:10226-54-7
Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg

Lastest Price from LOMIFYLLINE manufacturers

  • LOMIFYLLINE USP/EP/BP
  • US $1.10 / g
  • 2021-07-28
  • CAS:10226-54-7
  • Min. Order: 1g
  • Purity: 99.9%
  • Supply Ability: 100 Tons min
  • LOMIFYLLINE
  • US $1.00 / g
  • 2020-01-13
  • CAS:10226-54-7
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 200kg
  • lomifylline
  • US $1.00 / g
  • 2020-01-13
  • CAS:10226-54-7
  • Min. Order: 1g
  • Purity: 95-99%
  • Supply Ability: 1ton
LOMIFYLLINE Basic information
Product Name:LOMIFYLLINE
Synonyms:LOMIFYLLINE;3,7-Dihydro-1,3-dimethyl-7-(5-oxohexyl)-1H-purine-2,6-dione;1,3-DiMethyl-7-(5-oxohexyl)xanthine;7-(5-Oxohexyl)-1,3-diMethylxanthine;7-(5-Oxohexyl)theophylline;1,3-DiMethyl-7-(5-oxohexyl)-1H-purine-2,6(3H,7H)-dione;LoMifyllin;Cervilane
CAS:10226-54-7
MF:C13H18N4O3
MW:278.31
EINECS:233-547-0
Product Categories:
Mol File:10226-54-7.mol
LOMIFYLLINE Structure
LOMIFYLLINE Chemical Properties
storage temp. Sealed in dry,2-8°C
Safety Information
MSDS Information
LOMIFYLLINE Usage And Synthesis
OriginatorLomifylline,Yick-Vic Chemicals and
Manufacturing ProcessA mixture of 560 g of potassium carbonate, 700 ml of ethanol (96%), 404 g of 1,3-dibromopropane and 260 g of ethyl acetoacetate was heated with stirring to go 60°C. After the reaction had subsided, the reaction mixture was refluxed for 5 hours. Then the bulk of the alcohol was distilled off under ordinary pressure and the residue was mixed with 1.5 L of water. The resulting oily layer was separated, and the aqueous phase was extracted with benzene and the benzene layer was combined with the oil. After drying with sodium sulfate the benzene was distilled off and the residue was fractionally distilled 250 g (73% of theory) of 2-methyl-3-carbethoxy-5,6-dihydropyrane of boiling point 105°-108°C were obtained.
140 ml of 63% hydrobromic acid were slowly added at room temperature to 128 g of 2-methyl-3-carbethoxy-5,6-dihydropyrane, and much carbon dioxidewas evolved. After standing for 1 to 2 days at room temperature the mixture was diluted with an equal volume of iced water; the layer of dark colored oil formed was separated, the aqueous phase was extracted with chloroform, and the extract was combined with the oil and washed with a saturated solution of sodium bicarbonate. The solution was dried with sodium sulfate, the chloroform was distilled off under normal pressure, and the residue was fractionally distilled in vacuo. 109 g (81% of theory) of 1-bromohexanone-5 of boiling point 94°-98°C/12 mm Hg were obtained.
A solution of 10.0 g of 1-bromohexanone-5 in 100 ml of ethanol was gradually mixed at the boil with vigorous stirring with 11.3 g of the sodium salt of theophylline in 100 ml of water. After 3 hours refluxing the alcohol was distilled off, and the residual aqueous phase was cooled and made alkaline and extracted with chloroform. The chloroform solution was evaporated and the residue re-crystallized from a little isopropanol to yield 7-(5-oxohexyl) theophylline. MP: 75°-76°C; a yield of about 80% (calculated on the reacted theophylline).
Therapeutic FunctionVasodilator
Tag:LOMIFYLLINE(10226-54-7) Related Product Information
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