丁基硫
中文名称 | 丁基硫 |
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中文同义词 | DL-(3-氨基-4-羧丙基)-(S,R)-丁基硫氧亚胺;DL-丁硫氨酸(S,R)-亚砜亚胺;DL-丁硫氨酸-(S,R)-亚砜胺;DL-丁硫氨酸亚砜;丁基硫;丁硫胺酸亚砜胺(BSO);DL-丁硫氨酸-(S,R)-亚砜亚胺;DL-丁硫氨酸-S,R-磺基 |
英文名称 | DL-BUTHIONINE-[S,R]-SULFOXIMINE |
英文同义词 | DL-BUTHIONINE (R,S)-SULFOXIMINE;DL-BUTHIONINE-[S,R]-SULFOXIMINE;DL-BUTHIONINE (S,R)-SULPHOXIME;DL-BUTHIONINE-SULFOXIMINE;2-amino-4-(s-butylsulfonimidoyl)-butanoicaci;2-amino-4-(s-butylsulfonimidoyl)butanoicacid;buthioninesulfoxamine;buthioninesulfoximine |
CAS号 | 5072-26-4 |
分子式 | C8H18N2O3S |
分子量 | 222.31 |
EINECS号 | 628-045-7 |
相关类别 | Glutathione S-Transferase Agents;Sulfur & Selenium Compounds;D to;Drug and Xenobiotic Metabolism;Enzyme Inhibitors by Enzyme;Fusarinine -C OrnithinesteraseMulti-Drug Resistance and Drug Metabolism;Substrates, Inducers, Inhibitors |
Mol文件 | 5072-26-4.mol |
结构式 |
丁基硫 性质
熔点 | 215 °C (dec.)(lit.) |
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沸点 | 382.3±52.0 °C(Predicted) |
密度 | 1.29±0.1 g/cm3(Predicted) |
储存条件 | 2-8°C |
溶解度 | H2O:50 mg/mL,澄清,无色 |
形态 | 蓬松粉末 |
颜色 | 白色 |
Merck | 13,1520 |
BRN | 2367136 |
CAS 数据库 | 5072-26-4(CAS DataBase Reference) |
Target | Value |
GSH
() |
Buthionine sulfoximine is an analogs of methionine sulfoximine and inhibits gamma-glutamylcysteine synthetase about 20 times more effectively than prothionine sulfoximine and at least 100 times more effectively than methionine sulfoximine.
Treatment of mice bearing HT1080 and HT1080/DR4 xenografts with a continuous i.v infusion of nontoxic doses of D,L-Buthionine-(S,R)-sulfoximine (300 and 600 mg/kg/day) produce a 60% reduction of GSH plasma levels and greater than 95 % reduction in GSH tumor levels in both parental and multidrug-resistant tumors.
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