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| | 1,2-DIAMINO-4-(TRIFLUOROMETHOXY)BENZENE Basic information |
| Product Name: | 1,2-DIAMINO-4-(TRIFLUOROMETHOXY)BENZENE | | Synonyms: | 4-(Trifluoromethoxy)benzene-1,2-diamine 97%;4-Trifluoromethoxy-1,2-diaminobenzene;1,2-Diamino-4-(trifluoromethoxy)benzene, 4-(Trifluoromethoxy)phenylene-1,2-diamine;1,2-DIAMINO-4-(TRIFLUOROMETHOXY)BENZENE;4-(TRIFLUOROMETHOXY)-1,2-PHENYLENEDIAMINE;4-(TRIFLUOROMETHOXY)BENZENE-1,2-DIAMINE;4-(Trifluoromethoxy)-1,2-benzenediamine;1,2-Benzenediamine, 4-(trifluoromethoxy)- | | CAS: | 658-89-9 | | MF: | C7H7F3N2O | | MW: | 192.14 | | EINECS: | | | Product Categories: | Fluorine series | | Mol File: | 658-89-9.mol |  |
| | 1,2-DIAMINO-4-(TRIFLUOROMETHOXY)BENZENE Chemical Properties |
| Boiling point | 106-108 °C(Press: 5 Torr) | | density | 1.429±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | solubility | DMSO (Slightly), Methanol (Slightly) | | pka | 3.30±0.10(Predicted) | | form | Solid | | color | Dark Brown to Black | | Stability: | Air Sensitive |
| | 1,2-DIAMINO-4-(TRIFLUOROMETHOXY)BENZENE Usage And Synthesis |
| Uses | 1,2-Diamino-4-(trifluoromethoxy)benzene is a useful synthetic compound. | | Synthesis | General procedure for the synthesis of 4-(trifluoromethoxy)benzene-1,2-diamine from 2-nitro-4-trifluoromethoxyaniline: a solution of 2-nitro-4-trifluoromethoxyaniline (25.0 g, 0.112 mol) in ethanol (200 mL) was slowly added to a solution of concentrated hydrochloric acid (330 mL) of tin chloride dihydrate (82.0 g, 0.363 mol). The reaction mixture was stirred at 70-80°C for 0.5 hours. Upon completion of the reaction, the mixture was cooled to 0-5°C and the pH was adjusted to 11-12 with 40% sodium hydroxide solution.Subsequently, the reaction product was extracted with ether (2 x 200 mL). The organic phases were combined, washed with water and dried over anhydrous sodium sulfate. Finally, the solvent was removed by evaporation under reduced pressure to give 4-(trifluoromethoxy)benzene-1,2-diamine as a brown oil (21.1 g, 98% yield). | | References | [1] Patent: WO2006/50148, 2006, A2. Location in patent: Page/Page column 38
[2] Patent: WO2008/75109, 2008, A1. Location in patent: Page/Page column 160
[3] Patent: WO2006/130673, 2006, A1. Location in patent: Page/Page column 115
[4] Patent: WO2006/22954, 2006, A2. Location in patent: Page/Page column 24
[5] Patent: US2014/315963, 2014, A1. Location in patent: Paragraph 0228 |
| | 1,2-DIAMINO-4-(TRIFLUOROMETHOXY)BENZENE Preparation Products And Raw materials |
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