盐酸胺苯吖啶
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- CAS号:
- 54301-15-4
- 英文名:
- Amsacrine hydrochloride
- 英文别名:
- nsc141549;nci-c03190;M-AMSA, HCL;M-Amsacrine;Amsacrine HCI;META-AMSACRINE;AMSA hydrochloride;M-AMSA HYDROCHLORIDE;AMSACRINE HYDROCHLORIDE;acridinyl anisidide hydrochloride
- 中文名:
- 盐酸胺苯吖啶
- 中文别名:
- 胺苯丫啶;安沙克林;盐酸安吖啶;安吖啶盐酸盐;盐酸胺苯吖啶;盐酸胺苯吖啶, ≥98% (HPLC);N-[4-(9-吖啶基氨基)-3-甲氧基苯基]甲基磺酰胺;N-[4-(9-吖啶氨基)-3-甲氧苯基]甲基磺酰胺盐酸盐;4-(9-吖啶基氨基)-N-(甲磺酰基)-间甲氧基苯胺盐酸盐;盐酸胺苯吖啶,安吖啶,胺苯吖啶,N-[4-(9-吖啶基氨基)-3-甲氧基苯基]甲基磺酰胺
- CBNumber:
- CB4236395
- 分子式:
- C21H20ClN3O3S
- 分子量:
- 429.92
- MOL File:
- 54301-15-4.mol
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盐酸胺苯吖啶化学性质
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熔点:
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197-199 °C(lit.)
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储存条件:
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Refrigerator
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溶解度:
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DMSO: 10 mg/mL with heat and sonication
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形态:
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powder
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颜色:
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red to brown
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盐酸胺苯吖啶性质、用途与生产工艺
Amsacrine hydrochloride (m-AMSA hydrochloride; acridinyl anisidide hydrochloride) 是肿瘤细胞 DNA 嵌入剂,还能抑制拓扑异构酶 II。
Amsacrine (mAMSA) blocks HERG currents in HEK 293 cells and Xenopus oocytes in a concentration-dependent manner, with IC
50
values of 209.4 nM and 2.0 μM, respectively. Amsacrine (mAMSA) causes a negative shift in the voltage dependence of both activation (−7.6 mV) and inactivation (−7.6 mV). HERG current block by Amsacrine (mAMSA) is not frequency dependent. In vitro studies of normal human lymphocytes with various concentrations of Amsacrine (mAMSA), show both increased levels of chromosomal aberrations, ranging from 8% to 100%, and increase SCEs, ranging from 1.5 times the normal at the lowest concentration studied (0.005 μg/mL) to 12 times the normal (0.25 μg/mL). Amsacrine (mAMSA)-induced apoptosis of U937 cells is characterized by caspase-9 and caspase-3 activation, increased intracellular Ca
2+
concentration, mitochondrial depolarization, and MCL1 down-regulation. Amsacrine induces MCL1 down-regulation by decreasing its stability. Further, amsacrine-treated U937 cells show AKT degradation and Ca
2+
-mediated ERK inactivation.
In animals treated with different doses of amsacrine (0.5-12 mg/kg), the frequencies of micronucleated polychromatic erythrocytes increase significantly after treatment with 9 and 12 mg/kg. Furthermore, the present study demonstrates for the first time that Amsacrine (mAMSA) has high incidences of clastogenicity and low incidences of aneugenicity whereas nocodazole has high incidences of aneugenicity and low incidences of clastogenicity during mitotic phases in vivo.
用途
用作抗肿瘤药
类别
有毒物品
毒性分级
高毒
急性毒性
口服-小鼠LD50: 181 毫克/公斤; 腹腔-小鼠LD50: 20.56 毫克/公斤
可燃性危险特性
可燃; 加热分解释放有毒氮氧化物,硫氧化物和氯化氢烟雾
储运特性
库房通风低温干燥
灭火剂
干粉、泡沫、砂土、二氧化碳, 雾状水
盐酸胺苯吖啶
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-13551A | Amsacrine hydrochloride | | 5 mg | 360元 |
2024/08/19 | HY-13551A | 盐酸胺苯吖啶 Amsacrine hydrochloride | 54301-15-4 | 10mM * 1mLin DMSO | 396元 |
盐酸胺苯吖啶
生产厂家
全球有 104家供应商
盐酸胺苯吖啶国内生产厂家
54301-15-4, 盐酸胺苯吖啶 相关搜索:
- 生化试剂
- 高端化学
- 细胞生物学
- 细胞信号和神经生物学
- DNA Repair Regulators
- DNA metabolism
- Cell Signaling and Neuroscience
- Cell Biology
- BioChemical
- Apoptosis and Cell Cycle
- C21H19N3O3SHCl
- C21H19N3O3S
- 4-(9-吖啶基氨基)-N-(甲磺酰基)-间甲氧基苯胺盐酸盐
- 盐酸安吖啶
- 盐酸胺苯吖啶, ≥98% (HPLC)
- 胺苯丫啶
- 安沙克林
- N-[4-(9-吖啶基氨基)-3-甲氧基苯基]甲基磺酰胺
- 盐酸胺苯吖啶
- N-[4-(9-吖啶氨基)-3-甲氧苯基]甲基磺酰胺盐酸盐
- 安吖啶盐酸盐
- 盐酸胺苯吖啶,安吖啶,胺苯吖啶,N-[4-(9-吖啶基氨基)-3-甲氧基苯基]甲基磺酰胺
- 54301-15-4
- Amsacrine HCI
- acridinyl anisidide hydrochloride
- Amsacrine hydrochloride, ≥98% (HPLC)
- Amsacrine Hydrochloride, 4-(9-Acridinylamino)-N-(Methanesulfonyl)-M-Anisidine Hydrochloride
- AMSA hydrochloride
- nci-c03190
- n-(4-(9-acridinylamino)-3-methoxyphenyl)-methanesulfonamidmonohydrochlor
- 4’-(9-acridinylamino)-methanesulfonyl-m-anisidinmonohydrochloride
- 4’-(9-acridinylamino)-methanesulfon-m-anisididmonohydrochloride
- 4’-(9-acridinylamino)methanesulfon-m-anisidemonohydrochloride
- 4’-((9-acridinyl)amino)-methanesulfon-m-anisidinhydrochloride
- nsc141549
- AMSACRINE HYDROCHLORIDE
- AMine hydrochloride benzene acridine
- MethanesulfonaMide,N-[4-(9-acridinylaMino)-3-Methoxyphenyl]-, hydrochloride (1:1)
- N-(4-(acridin-9-ylaMino)-3-Methoxyphenyl)MethanesulfonaMide hydrochloride
- META-AMSACRINE
- M-Amsacrine
- Methanesulfonamide, N-4-(9-acridinylamino)-3-methoxyphenyl-, monohydrochloride
- M-AMSA, HCL
- M-AMSA HYDROCHLORIDE
- 4-[9-ACRIDINYLAMINO]-N-[METHANE-SULFONYL]-M-ANISIDINE HYDROCHLORIDE
- Methansulfon-m-aniside, 4'-(9-acridinylamino)-, monohydrochloride
- Methanesulfon-m-anisidide 4'-(9-acridinylamino)-
- Methanesulfone-m-anisidine-4'-[(9-acridinyl)amino] hydrochloride
- m-AMSA, 4-(9-Acridinylamino)-N-(methanesulfonyl)-m-anisidine hydrochloride