Amsacrine hydrochloride

Amsacrine hydrochloride Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: 21-51619050
Email: ivan@atkchemical.com
Products Intro: Product Name:Amsacrine hydrochloride
CAS:54301-15-4
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: HENAN BON INDUSTRIAL CO.,LTD
Tel: 0371-55170695
Email: info@hnbon.com
Products Intro: CAS:54301-15-4
Purity:0.99 Package:25KG;5KG;1KG;500G
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427
Email: sales@conier.com
Products Intro: Product Name:amsacrine hydrochloride
CAS:54301-15-4
Purity:99% Package:1kg
Company Name: career henan chemical co
Tel: +86-0371-86658258
Email: factory@coreychem.com
Products Intro: Product Name:Amsacrine hydrochloride
CAS:54301-15-4
Purity:99.0% Package:1g;1USD
Company Name: SIMAGCHEM CORP
Tel: +86-13806087780 +86-13806087780
Email: sale@simagchem.com
Products Intro: Product Name:Amsacrine Hydrochloride, 4-(9-Acridinylamino)-N-(Methanesulfonyl)-M-Anisidine Hydrochloride
CAS:54301-15-4
Purity:0.99 Package:1kg,5kg,25kgs,200kgs;bulk

Amsacrine hydrochloride manufacturers

Amsacrine hydrochloride Basic information
Product Name:Amsacrine hydrochloride
Synonyms:m-AMSA, 4-(9-Acridinylamino)-N-(methanesulfonyl)-m-anisidine hydrochloride;Methanesulfone-m-anisidine-4'-[(9-acridinyl)amino] hydrochloride;Methanesulfon-m-anisidide 4'-(9-acridinylamino)-;Methansulfon-m-aniside, 4'-(9-acridinylamino)-, monohydrochloride;4-[9-ACRIDINYLAMINO]-N-[METHANE-SULFONYL]-M-ANISIDINE HYDROCHLORIDE;M-AMSA HYDROCHLORIDE;M-AMSA, HCL;Methanesulfonamide, N-4-(9-acridinylamino)-3-methoxyphenyl-, monohydrochloride
CAS:54301-15-4
MF:C21H20ClN3O3S
MW:429.92
EINECS:637-255-8
Product Categories:
Mol File:54301-15-4.mol
Amsacrine hydrochloride Structure
Amsacrine hydrochloride Chemical Properties
Melting point 197-199 °C(lit.)
storage temp. Refrigerator
solubility DMSO: 10 mg/mL with heat and sonication
form powder
color red to brown
Safety Information
Hazard Codes T
Risk Statements 25-36/37/38
Safety Statements 26-45
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS PB1081000
HazardClass 6.1(b)
PackingGroup III
MSDS Information
Amsacrine hydrochloride Usage And Synthesis
UsesAmsacrine hydrochloride has been used:
  • as a topoisomerase poison in bacteriophage T4 topoisomerase assay
  • as a topoisomerase inhibitor in Drosophila cell line, Kc167
  • as an antileukemia drug to test its effect on p53 transcriptional activity in tumor xenografts
  • as a topoisomerase II poison in dose-response assays in C elegans

Biological Activityamsacrine hydrochloride (amsidine, m-amsa) is an inhibitor of topoisomerase 2 [1].amsacrine hydrochloride is a chemotherapy drug of antineoplastic, used to treat some types of lymphoma and acute leukaemia. in addition, amsacrine hydrochloride has shown the sensitivities to the cancer cell lines with the ic50 values of 190.2±27.4ng/ml, 46.1±3.9ng/ml,22.6±3.1ng/ml, 11.8±2.0ng/ml, 5.0±0.4ng/ml, and 11.7±1.5ng/ml for three bladder cancer cell lines (ht1376,rt112, rt4) and three testis cancer cell lines(833k, susa, gh), respectively. and it has been found that the testis tumor cell lines are more sensitive to inhibiting by amsacrine hydrochloride than the bladder cell lines [1].
Biochem/physiol ActionsAmsacrine (m-AMSA) is a derivative of acridine and an antileukemia drug. It is an anticancer drug with antineoplastic activity that targets topoisomerase II. AMSA is an apoptosis inducer and favors the accumulation of double-stranded breaks (DSBs). It also inhibits the expression of matrix metallopeptidase 2 (MMP-2) and MMP-9 expression in leukemia cells by generating reactive oxygen species (ROS). AMSA serves as an adjuvant in trabeculectomy surgery.
references[1] nelson em, tewey km, liu lf. mechanism of antitumor drug action: poisoning of mammalian dna topoisomerase ii on dna by 4'-(9-acridinylamino)-methanesulfon-m-anisidide. proc natl acad sci u s a. 1984 mar;81(5):1361-5.
Amsacrine hydrochloride Preparation Products And Raw materials
Preparation ProductsAmsacrine
Tag:Amsacrine hydrochloride(54301-15-4) Related Product Information
Methanesulfonamide Amsacrine/Amsacrine hydrochloride,Amsacrine/Amsacrine hydrochloride 3-Hydroxytyramine hydrochloride 9(10H)-ACRIDONE 6,9-DIAMINO-2-ETHOXYACRIDINE LACTATE DL-Norephedrine hydrochloride Basic Orange 14 M-ANISIDINE HYDROCHLORIDE Amsacrine, HCl amsacrine-DNA amsacrine-tetrachloroplatinum dianion complex Amsacrine hydrochloride 2-ETHOXY-6,9-DIAMINOACRIDINE anisidine Methoxyammonium chloride Diphenhydramine Hydrochloride Topotecan hydrochloride Benzhexol hydrochloride