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| | 2,4'-Dibromoacetophenone Basic information |
| | 2,4'-Dibromoacetophenone Chemical Properties |
| Melting point | 108-110 °C(lit.) | | Boiling point | 1415°C/760mm | | density | 1.7855 (rough estimate) | | refractive index | 1.5560 (estimate) | | storage temp. | Store below +30°C. | | solubility | DMF: 5 mg/ml; DMSO: 2 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): insol | | form | Crystalline Solid | | color | Slightly yellow to beige | | Water Solubility | Soluble in dimethyl sulfoxide (5 mg/ml), methanol (20 mg/ml), toluene and ethanol. Insoluble in water. | | Sensitive | Lachrymatory | | Merck | 14,1427 | | BRN | 607604 | | Stability: | Stable. Incompatible with strong bases, strong reducing agents, strong oxidizing agents. | | InChIKey | FKJSFKCZZIXQIP-UHFFFAOYSA-N | | CAS DataBase Reference | 99-73-0(CAS DataBase Reference) | | EPA Substance Registry System | Ethanone, 2-bromo-1-(4-bromophenyl)- (99-73-0) |
| Hazard Codes | C | | Risk Statements | 34 | | Safety Statements | 26-36/37/39-45 | | RIDADR | UN 3261 8/PG 2 | | WGK Germany | 2 | | RTECS | AM6950000 | | F | 19-21 | | Hazard Note | Corrosive/Lachrymatory | | TSCA | T | | HazardClass | 8 | | PackingGroup | III | | HS Code | 29147090 |
| | 2,4'-Dibromoacetophenone Usage And Synthesis |
| Chemical Properties | 2,4'-Dibromoacetophenone is off-white crystals or powder | | Uses | Identification of carboxylic acids. | | Uses | Undergoes condensation reactions with aldehydes in the presence of SnCl21 or SmI32 to afford α,β-unsaturated ketones. Also useful in the esterification of carboxylic acids.3 | | Uses | 2,4'-Dibromoacetophenone is used as a reagent for analysis of fatty acids by HPLC as 4-bromophenacyl esters, for use in the protection of phenols and carboxylic acids. It undergoes condensation reactions with aldehydes in the presence of SnCl2 or SmI3 to afford α,β-unsaturated ketones. It is also useful in the esterification of carboxylic acids. | | General Description | A phenyl α-bromomethyl ketone compound that acts as a cell-permeable, and non-ATP competitive inhibitor of GSK-3β (IC50 = 0.5 μM). This reactive alkylating agent is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 μM. | | Biochem/physiol Actions | Cell permeable: yes | | Purification Methods | Crystallise the bromide from EtOH (ca 8mL/g). [Beilstein 7 IV 652.] |
| | 2,4'-Dibromoacetophenone Preparation Products And Raw materials |
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