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| | 4,4'-Difluorobenzhydrol Basic information |
| | 4,4'-Difluorobenzhydrol Chemical Properties |
| Melting point | 43-45 °C(lit.) | | Boiling point | 143 °C3 mm Hg(lit.) | | density | 1.2031 (estimate) | | Fp | >230 °F | | storage temp. | Sealed in dry,Room Temperature | | pka | 13.41±0.20(Predicted) | | form | powder to crystal | | color | White to Light yellow | | BRN | 2332258 | | InChI | InChI=1S/C13H10F2O/c14-11-5-1-9(2-6-11)13(16)10-3-7-12(15)8-4-10/h1-8,13,16H | | InChIKey | WCTZPQWLFWZYJE-UHFFFAOYSA-N | | SMILES | C(O)(C1C=CC(F)=CC=1)C1C=CC(F)=CC=1 | | CAS DataBase Reference | 365-24-2(CAS DataBase Reference) | | NIST Chemistry Reference | 4,4'-Difluorobenzhydrol(365-24-2) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 22-24/25-36/37-26 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29062900 | | Storage Class | 11 - Combustible Solids |
| | 4,4'-Difluorobenzhydrol Usage And Synthesis |
| Chemical Properties | white to yellowish crystalline flakes or powder | | Uses | 4-Chloropyridine-3-sulfonyl Chloride can be used for antiinflammatory properties. | | General Description | Bis(4-fluorophenyl)methanol is one of the degardation product of flunarizine hydrochloride (FLZ). | | Synthesis | GENERAL METHODS: NaBH4 (0.6 mol) was added batchwise to a stirred solution of 4,4'-difluorobenzophenone (1.0 mol) in methanol (2 volumes) at room temperature for 45 min. The reaction mixture was stirred at ambient temperature for 2-3 h (progress of the reaction was monitored by TLC), and upon completion of the reaction, the reaction was diluted with water (750 mL), the pH was adjusted to 4 with acetic acid, and the reaction was subsequently extracted with dichloromethane (2 x 400 mL). The organic layer was washed with water (200 mL), dried with anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give pure 4,4'-difluorodiphenylmethanol as a white to off-white solid in 93-97% yield.
To a stirred solution of 4,4'-difluorodiphenylmethanol (1.0 mol) in toluene (370 mL) at room temperature was added concentrated hydrochloric acid (35% aqueous, 370 mL) and tetrabutylammonium bromide (0.01 mol). The mixture was continued to be stirred at 40-45 °C for 6-7 h. After TLC showed that the reaction was complete, the mixture was cooled to room temperature. The organic layer was separated and concentrated under vacuum to give crude 4,4'-difluorodiphenylmethyl chloride as a light brown liquid in 95-97% yield.
Anhydrous piperazine (5.0 mol) was slowly added to a solution of 4,4'-difluorodiphenylmethyl chloride (0.96 mol) in toluene (380 mL) at 60-70 °C for 45-60 minutes. The resulting mixture was heated at 90-100°C for 8-10 hours with stirring. After completion of the reaction the mixture was cooled and water (380 mL) was added to separate the organic layer. The organic layer was washed with a 1:1 mixture of concentrated hydrochloric acid and water (2 x 350 mL) and subsequently neutralized with 20% NaOH solution (750 mL). The aqueous layer was again extracted with toluene (2×300 mL), and the organic layers were combined, dried with anhydrous sodium sulfate, and concentrated in vacuum to afford the pure 4,4'-difluorodiphenylmethylpiperazine derivative as a white to off-white solid in 88% yield. | | References | [1] Organic and Biomolecular Chemistry, 2018, vol. 16, # 28, p. 5094 - 5096
[2] Synthesis, 2010, # 12, p. 1989 - 1991
[3] Synthetic Communications, 2014, vol. 44, # 5, p. 600 - 609
[4] Organic Letters, 2000, vol. 2, # 5, p. 659 - 661
[5] Patent: , 2016, . Location in patent: Paragraph 0016; 0018; 0019; 0020; 0021; 0022 |
| | 4,4'-Difluorobenzhydrol Preparation Products And Raw materials |
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