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| | 6-Chloro-1H-indole-2-carbaldehyde Basic information |
| | 6-Chloro-1H-indole-2-carbaldehyde Chemical Properties |
| Boiling point | 373.4±22.0 °C(Predicted) | | density | 1.431±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 14.15±0.30(Predicted) | | Appearance | Light yellow to brown Solid |
| | 6-Chloro-1H-indole-2-carbaldehyde Usage And Synthesis |
| Chemical Properties | Brown solid | | Synthesis | GENERAL STEPS: A suspension of 2-hydroxymethyl-6-chloroindole (1 mmol) with activated MnO2 (10 mmol) in DMF (30 mL) was stirred at room temperature for 12 hours. After completion of the reaction, the mixture was filtered through a diatomaceous earth pad. The filtrate was concentrated under vacuum and the residue was purified by column chromatography to afford 6-chloro-1H-indole-2-carbaldehyde using EtOAc-hexane mixed solvent as eluent. | | References | [1] European Journal of Medicinal Chemistry, 2016, vol. 121, p. 561 - 577
[2] Patent: US2003/144282, 2003, A1
[3] Journal of Medicinal Chemistry, 2007, vol. 50, # 6, p. 1380 - 1400
[4] Patent: US2008/9485, 2008, A1. Location in patent: Page/Page column 31
[5] Journal of Medicinal Chemistry, 2014, vol. 57, # 2, p. 364 - 377 |
| | 6-Chloro-1H-indole-2-carbaldehyde Preparation Products And Raw materials |
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