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| | 6-Chloroindole-2-carboxylic acid ethyl ester Basic information |
| | 6-Chloroindole-2-carboxylic acid ethyl ester Chemical Properties |
| Melting point | 169-171 °C | | Boiling point | 375.0±22.0 °C(Predicted) | | density | 1.329±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | Solid | | pka | 14.11±0.30(Predicted) | | Appearance | Light brown to gray Solid | | CAS DataBase Reference | 27034-51-1(CAS DataBase Reference) |
| | 6-Chloroindole-2-carboxylic acid ethyl ester Usage And Synthesis |
| Uses | Ethyl 6-chloroindole-2-carboxylate is an organic compound mainly used as a pharmaceutical intermediate and chemical reagent. | | Synthesis | General method: 6a-d (9.2 mmol) was dissolved in toluene (150 mL) under nitrogen protection, rhodium(II) acetate dimer (203 mg, 0.46 mmol) was added, and the reaction was heated to reflux for 1-2 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure, and the resulting residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate, 25:1 to 18:1, v/v) to afford the target product ethyl 6-chloroindole-2-carboxylate (7a-d) in 51.7%-58.6% overall yields. | | References | [1] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 6, p. 1760 - 1762
[2] Journal of Medicinal Chemistry, 1991, vol. 34, # 4, p. 1283 - 1292 |
| | 6-Chloroindole-2-carboxylic acid ethyl ester Preparation Products And Raw materials |
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