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| | 2-Chloro-5-Methoxy-pyriMidin-4-ylaMine Basic information |
| Product Name: | 2-Chloro-5-Methoxy-pyriMidin-4-ylaMine | | Synonyms: | 2-Chloro-5-Methoxy-pyriMidin-4-ylaMine;2-Chloro-5-Methoxy-4-pyriMidinaMine;4-Amino-2-chloro-5-methoxypyrimidine;4-Pyrimidinamine, 2-chloro-5-methoxy-;2-Chloro-5-Methoxy-pyriMidin-4-ylaMine ISO 9001：2015 REACH;2-chloro-5-MethoxypyriMidin-4-aMine;2-Chloro-4-amino-5-methoxypyrimidine | | CAS: | 99979-77-8 | | MF: | C5H6ClN3O | | MW: | 159.57 | | EINECS: | | | Product Categories: | | | Mol File: | 99979-77-8.mol |  |
| | 2-Chloro-5-Methoxy-pyriMidin-4-ylaMine Chemical Properties |
| Melting point | 181-182 °C (decomp)(Solv: ligroine (8032-32-4)) | | Boiling point | 349.6±22.0 °C(Predicted) | | density | 1.398±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 2.39±0.10(Predicted) | | Appearance | White to light brown Solid |
| | 2-Chloro-5-Methoxy-pyriMidin-4-ylaMine Usage And Synthesis |
| Uses | The preparation and synthesis of 2-Chloro-5-methoxy-4-pyrimidinamine. | | Synthesis | 2-Chloro-5-methoxypyrimidin-4-amine was synthesized as follows: 2,4-dichloro-5-methoxypyrimidine (10 g, 56.17 mmol) was dissolved in 1,4-dioxane (20 mL) under argon protection and stirred at room temperature. Subsequently, ammonium hydroxide (25.5 mL) was slowly added to the solution. The reaction mixture was transferred to a sealed tube, heated to 100 °C and maintained for 21 hours. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the volatile components were evaporated under reduced pressure. The crude product was purified by silica gel column chromatography with 40% ethyl acetate/hexane as eluent to afford 2-chloro-5-methoxypyrimidin-4-amine (8.9 g, 99% yield) as an off-white solid. The structure of the product was confirmed by 1H-NMR (DMSO-d6, 500MHz): δ7.68 (s, 1H), 3.81 (s, 3H); LC-MS (column: X-Bridge C-18, 50×3.0 mm, 3.5 μm; mobile phase: 0.05% aqueous trifluoroacetic acid/acetonitrile; flow rate: 0.80 mL/min) showed m/z 160 ([M+H]+), retention time 2.18 min; TLC (unfolding agent: 50% ethyl acetate/hexane) showed an Rf value of 0.3. | | References | [1] Patent: WO2015/66697, 2015, A1. Location in patent: Paragraph 0345; 0416
[2] Patent: WO2011/59839, 2011, A1. Location in patent: Page/Page column 91
[3] Patent: WO2015/86506, 2015, A1. Location in patent: Page/Page column 103
[4] Patent: CN105218561, 2016, A. Location in patent: Paragraph 0242; 0243; 0244
[5] Patent: WO2009/150240, 2009, A1. Location in patent: Page/Page column 128 |
| | 2-Chloro-5-Methoxy-pyriMidin-4-ylaMine Preparation Products And Raw materials |
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