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iOWH-032

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Company Name: ATK CHEMICAL COMPANY LIMITED
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Products Intro: Product Name:IOWH032
CAS:1191252-49-9
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 18871490254
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Products Intro: Product Name:iOWH-032
CAS:1191252-49-9
Purity:0.99 Package:5KG;1KG
Company Name: career henan chemical co
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Products Intro: Product Name: iOWH-032
CAS:1191252-49-9
Purity:99% Package:1g;1USD
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
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Products Intro: Product Name:IOWH-032;IOWH032;IOWH 032
CAS:1191252-49-9
Purity:100.00% Package:1 mL * 10mM (in DMSO);10 mg;100 mg;200 mg;25 mg;5 mg;50 mg;500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226
Email: sales@hzclap.com
Products Intro: Product Name:IOWH-032
CAS:1191252-49-9
Purity:99% Package:10kg 25kg 200 kilograms per barrel Remarks:good

iOWH-032 manufacturers

  • iOWH-032
  • 	iOWH-032 pictures
  • $1.00 / 1g
  • 2020-01-14
  • CAS:1191252-49-9
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 200kg
iOWH-032 Basic information
Description In vitro In vivo
Product Name:iOWH-032
Synonyms:3-(3,5-DibroMo-4-hydroxyphenyl)-N-(4-phenoxybenzyl)-1,2,4-oxadiazole-5-carboxaMide;iOWH-032;3-(3,5-Dibromo-4-hydroxyphenyl)-N-[(4-phenoxyphenyl)methyl]-1,2,4-oxadiazole-5-carboxamide;1,2,4-Oxadiazole-5-carboxamide, 3-(3,5-dibromo-4-hydroxyphenyl)-N-[(4-phenoxyphenyl)methyl]-;3-(3,5-Dibromo-4-hydroxyphenyl)-N-[(4-phenoxyphenyl)methyl]-1,2,4-oxadiazole-5-carboxamide IOWH032;3-(3,5-DIBROMO-4-OXOCYCLOHEXA-2,5-DIEN-1-YLIDENE)-N-[(4-PHENOXYPHENYL)METHYL]-1,2,4-OXADIAZOLE-5-CARBOXAMIDE;IOWH-032; IOWH032; IOWH 032;CS-950
CAS:1191252-49-9
MF:C22H15Br2N3O4
MW:545.18
EINECS:
Product Categories:Inhibitors
Mol File:1191252-49-9.mol
iOWH-032 Structure
iOWH-032 Chemical Properties
density 1.670±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility ≥21.85 mg/mL in DMSO; insoluble in H2O; ≥3.13 mg/mL in EtOH with gentle warming
form solid
pka3.34±0.46(Predicted)
Safety Information
MSDS Information
iOWH-032 Usage And Synthesis
DescriptionIOWH032 is a synthetic CFTR inhibitor with IC50 of 1.01 μM in CHO-CFTR cell based assays. Phase 2.
In vitroIOWH032 shows inhibitory activity against CFTR in T84-CFTR cell based assays with IC50 of 6.87 μM.
In vivoIn a mouse closed-loop model, IOWH032 causes a statistical significant inhibition against cholera toxin (CTX) induced secretion. IOWH032 (5 mg/kg) reduces the fecal output index by ~70% in a cecetomized rat model.
UsesIOWH032 is a synthetic?cystic fibrosis transmembrane conductance regulator (CFTR) ?inhibitor.
Biological Activityiowh-032 is a potent and synthetic extracellular cystic fibrosis transmembrane conductance regulator (cftr) inhibitor with ic50 value of 1.01 μm in t84 and cho-cftr cell based assays [1]. the cftr chloride channel is the most attractive because it is the primary driver of secretion in cases of diarrhea caused by enterotoxigenic bacteria. cftr plays an important role in transepithelial fluid homeostasis through controlling the flow of chloride ions and thus the movement of water in and out of cells [1].
in vitroiowh032 inhibited cftr activity with ic50 value of 6.87 μm in t84-cftr cell based assays [1]. iowh-032 rapidly blocked and potentiated hcftr activity in a concentration-dependent manner with apparent kd value of 6.1 nm and 0.64 nm, respectively. however, iowh-032 did not potentiate and only blocked mcftr with an apparent kd value of 42.9 μm [2].
in vivoiowh032 significantly inhibited cholera toxin (ctx)-induced secretion in a mouse closed-loop model. moreover, iowh032 (5 mg/kg, po dose) decreased the fecal output index by apparent 70% compared to vehicle (cholera toxin) in a cecetomized rat model. iowh032 inhibited cftr activity with ic50 value of 6.87 μm in t84-cftr cell based assays [1].
targetcftr
IC 501.01 μm
references1. doyle k, et al. inhibitors of the cftr chloride ion channel as potential treatment for acute secretory diarrhea: development of 5-membered heterocycles suitable for pre-clinical evaluation.1. de hostos el, choy rk, nguyen t. developing novel antisecretory drugs to treat infectious diarrhea. future med chem. 2011;3(10):1317-25. 2. cui g, khazanov n, stauffer b, infield dt, imhoff br, senderowitz h, et al. potentiators exert distinct effects on human, murine, and xenopus cftr. am j physiol lung cell mol physiol. 2016:ajplung 00056 2016.
iOWH-032 Preparation Products And Raw materials
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