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| | 1-(4-BROMOPHENYL)PIPERAZINE HYDROCHLORIDE Basic information |
| Product Name: | 1-(4-BROMOPHENYL)PIPERAZINE HYDROCHLORIDE | | Synonyms: | 1-(4-BROMOPHENYL)-PIPERAZINE HCL;1-(4-BROMOPHENYL)PIPERAZINE HYDROCHLORIDE;RARECHEM AH CK 0050;1-(4-Bromophenyl)piperazine hydrochloride 98%;1-(4-Bromophenyl)-piperazine x HCl;1-(4-Bromophenyl)piperazin HCl;1-(4-BROMOPHENYL)PIPERAZINE HYDROCHLORIDE ISO 9001：2015 REACH;1-(4-Bromophenyl)piperazineHydrochloride> | | CAS: | 68104-62-1 | | MF: | C10H14BrClN2 | | MW: | 277.59 | | EINECS: | | | Product Categories: | Pyrazines;Heterocycles;Piperazines | | Mol File: | 68104-62-1.mol |  |
| | 1-(4-BROMOPHENYL)PIPERAZINE HYDROCHLORIDE Chemical Properties |
| Melting point | >280°C (dec.) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | DMSO: 10 mg/ml; PBS (pH 7.2): 10 mg/ml | | Water Solubility | Soluble in water | | form | powder to crystal | | color | White to Almost white | | InChI | InChI=1S/C10H13BrN2.ClH/c11-9-1-3-10(4-2-9)13-7-5-12-6-8-13;/h1-4,12H,5-8H2;1H | | InChIKey | YDVSFRZKQMQPJD-UHFFFAOYSA-N | | SMILES | C1(C=CC(Br)=CC=1)N1CCNCC1.Cl | | CAS DataBase Reference | 68104-62-1(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36/37/39 | | Hazard Note | Irritant | | HS Code | 2933.59.8000 |
| | 1-(4-BROMOPHENYL)PIPERAZINE HYDROCHLORIDE Usage And Synthesis |
| Description | 1-(4-Bromophenyl)piperazine hydrochloride is an important organic synthetic intermediate, playing a crucial role, especially in medicinal chemistry. It is not typically used as a final product, but rather introduced as a structural unit (i.e., a "building block") into more complex molecules to construct drug molecules with specific biological activities. The "p-bromophenyl" and "piperazine ring" contained in its structure are common pharmacophores in many central nervous system drugs, such as antipsychotics and antidepressants. | | Uses | 1-(4-Bromophenyl)piperazine Hydrochloride is useful in the synthesis of large bifunctional heterocycles use in targeted degradation of rapidly accelerated fibrosarcoma polypeptides | | Synthesis | P-Bromoaniline undergoes a biphilic nucleophilic substitution reaction with bis(2-chloroethyl)amine in the presence of a base (e.g., sodium carbonate) to directly generate 1-(4-bromophenyl)piperazine. Finally, 1-(4-bromophenyl)piperazine reacts with hydrochloric acid to synthesize 1-(4-bromophenyl)piperazine hydrochloride. |
| | 1-(4-BROMOPHENYL)PIPERAZINE HYDROCHLORIDE Preparation Products And Raw materials |
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